Results 271 to 280 of about 218,906 (301)
Inferring Meaningful Pathways in Weighted Metabolic Networks [PDF]
Journal of Molecular Biology, 2006 An approach is presented for computing meaningful pathways in the network of small molecule metabolism comprising the chemical reactions characterized in all organisms. The metabolic network is described as a weighted graph in which all the compounds are included, but each compound is assigned a weight equal to the number of reactions in which it ...
Shoshana J Wodak, Jacques Van Helden
exaly +5 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Neural Networks for Modeling Metabolic Pathways
Series in Bioengineering, 2021Metabolic pathways are enzyme-catalyzed reactions that can be described by the Michaelis-Menten equation. The inherent problem with Michaelis-Menten kinetics is that the model is not reversible. Reverse catalysis, which is common in metabolic pathways, can be better described by Cell Communication Protocol© which offers a Self-Organizing Map (SOM) for ...
Meir Israelowitz +2 more
exaly +2 more sources
Prediction of metabolic pathways from genome-scale metabolic networks
BioSystems, 2011The analysis of a variety of data sets (transcriptome arrays, phylogenetic profiles, etc.) yields groups of functionally related genes. In order to determine their biological function, associated gene groups are often projected onto known pathways or tested for enrichment of known functions.
Karoline Faust, Jacques Van Helden
exaly +5 more sources
Predicting novel pathways in genome-scale metabolic networks
Biochemical Society Transactions, 2010 Elementary-modes analysis has become a well-established theoretical tool in metabolic pathway analysis. It allows one to decompose complex metabolic networks into the smallest functional entities, which can be interpreted as biochemical pathways. This analysis has, in medium-size metabolic networks, led to the successful theoretical prediction of ...
Stefan, Schuster +2 more
openaire +3 more sources
Analysis of the pathway structure of metabolic networks
Journal of Biotechnology, 1999Metabolic networks comprise a multitude of enzymatic reactions carrying out various functions related to cell growth and product formation. Although such reactions are occasionally organized into biochemical pathways, a formal procedure is desired to identify the independent pathways in a bioreaction network and the degree of engagement of each ...
T W, Simpson +2 more
openaire +2 more sources
Pathway knockout and redundancy in metabolic networks
Journal of Theoretical Biology, 2011The robustness and stability of complex cellular networks is often attributed to the redundancy of components, including genes, enzymes and pathways. Estimation of redundancy is still an open question in systems biology. Current theoretical tools to measure redundancy have various strengths and shortcomings in providing a comprehensive description of ...
Yong, Min +5 more
openaire +2 more sources
Combinatorial Complexity of Pathway Analysis in Metabolic Networks
Molecular Biology Reports, 2002Elementary flux mode analysis is a promising approach for a pathway-oriented perspective of metabolic networks. However, in larger networks it is hampered by the combinatorial explosion of possible routes. In this work we give some estimations on the combinatorial complexity including theoretical upper bounds for the number of elementary flux modes in ...
Steffen, Klamt, Jörg, Stelling
openaire +4 more sources
Gene Networks Validation based on Metabolic Pathways
2011 IEEE 11th International Conference on Bioinformatics and Bioengineering, 2011In the last few years, DNA microarray technology has attained a very important role in biological and biomedical research. It enables analyzing the relations among thousands of genes simultaneously, generating huge amounts of data. The gene networks represent, in a graph data structure, genes or gene products and the functional relationships between ...
Francisco Gómez-Vela +2 more
openaire +1 more source
Finding Feasible Pathways in Metabolic Networks
2005Recent small-world studies of the global structure of metabolic networks have been based on the shortest-path distance. In this paper, we propose new distance measures that are based on the structure of feasible metabolic pathways between metabolites.
Esa Pitkänen +3 more
openaire +1 more source