Results 311 to 320 of about 1,386,772 (353)
Some of the next articles are maybe not open access.
Metabolic Pathways of Ochratoxin A
Current Drug Metabolism, 2011Ochratoxin A (OTA) as a carcinogenic of group 2B to humans is produced by various fungi strains as Aspergillus and Penicillium. It is one of the most common contaminant in foodstuff. OTA is nephrotoxic, hepatotoxic, teratogenic, and immunotoxic and is assumed to cause Balkan Endemic Nephropathy (BEN), a chronic kidney disease in humans when it is ...
Zonghui Yuan +6 more
openaire +3 more sources
Chromokinetics of metabolic pathways
European Journal of Biochemistry, 2004Some methods to study and intuitively understand steady‐state flows in complicated metabolic pathways are discussed. For this purpose, a suitable decomposition of complex metabolic schemes into smaller subsystems is used. These independent subsystems are then interpreted as basic colors of a chromatic coloring scheme.
openaire +3 more sources
2016
Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Adrian J. Shepherd, Jan M. Czarnecki
openaire +3 more sources
Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Adrian J. Shepherd, Jan M. Czarnecki
openaire +3 more sources
Endocannabinoid Metabolic Pathways and Enzymes
Current Drug Target -CNS & Neurological Disorders, 2005Endocannabinoids, defined in 1995 as endogenous agonists of cannabinoid receptors, their anabolic and catabolic pathways, and the enzymes involved in these pathways (the "endocannabinoid enzymes"), are the subject of this review. A general strategy seems to apply to the regulation of the levels of the two major endocannabinoids, anandamide and 2 ...
Ligresti A, Cascio MG, Di Marzo V
openaire +3 more sources
On representation of metabolic pathways
Biosystems, 1998Problems involved in representation of metabolism are dealt with. The specific characteristics of the various ways (verbal, graphical and by electronic means), their advantages and limitations are discussed. New developments in research pose challenges for adequate and clear demonstration of results. Comments on nomenclature and on style are included.
openaire +3 more sources
Metabolic Pathways in the Apicoplast of Apicomplexa
2010Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called apicoplast that is the most reduced organelle of this type known. Due to the medical importance of some members of Apicomplexa, a number of fully sequenced genomes are available that have allowed to assemble metabolic pathways also from the apicoplast and have ...
Seeber, Frank, Soldati-Favre, Dominique
openaire +4 more sources
1986
The routes by which drugs may be metabolised or biotransformed are many and varied and include the chemical reactions of oxidation, reduction, hydrolysis, hydration, conjugation and condensation. It is important that these pathways are studied as the route of metabolism of a drug can determine whether it shows any pharmacological or toxicological ...
Paul Skett, G. Gordon Gibson
openaire +2 more sources
The routes by which drugs may be metabolised or biotransformed are many and varied and include the chemical reactions of oxidation, reduction, hydrolysis, hydration, conjugation and condensation. It is important that these pathways are studied as the route of metabolism of a drug can determine whether it shows any pharmacological or toxicological ...
Paul Skett, G. Gordon Gibson
openaire +2 more sources
Metabolic pathways regulated by p63
Biochemical and Biophysical Research Communications, 2017The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively ...
Gerry Melino +11 more
openaire +4 more sources
Salvage pathways in glycosphingolipid metabolism
Biochimie, 2003In this review, the focus is on the role of salvage pathways in glycosphingolipid, particularly, ganglioside metabolism. Ganglioside de novo biosynthesis, that begins with the formation of ceramide and continues with the sequential glycosylation steps producing the oligosaccharide moieties, is briefly outlined in its enzymological and cell-topological ...
G. Tettamanti +3 more
openaire +3 more sources
Identifying Branched Metabolic Pathways by Merging Linear Metabolic Pathways
2011This paper presents a graph-based algorithm for identifying complex metabolic pathways in multi-genome scale metabolic data. These complex pathways are called branched pathways because they can arrive at a target compound through combinations of pathways that split compounds into smaller ones, work in parallel with many compounds, and join compounds ...
George N. Bennett +2 more
openaire +1 more source