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Methods in molecular biology, 2016
Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Adrian J. Shepherd, Jan M. Czarnecki
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Understanding metabolic pathways is one of the most important fields in bioscience in the post-genomic era, but curating metabolic pathways requires considerable man-power. As such there is a lack of reliable, experimentally verified metabolic pathways in databases and databases are forced to predict all but the most immediately useful pathways.Text ...
Adrian J. Shepherd, Jan M. Czarnecki
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The role and mechanism of tryptophan – kynurenine metabolic pathway in depression
Reviews in the Neurosciences, 2022Major depressive disorder (MDD) is a common mental illness characterized by persistent low mood and anhedonia, normally accompanied with cognitive impairment. Due to its rising incidence and high rate of recurrence and disability, MDD poses a substantial
Xiaoli Gong +4 more
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Metabolic pathways of trichothecenes
Drug Metabolism Reviews, 2009Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-
Kamil Kuca +4 more
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On the Origin of Metabolic Pathways
Journal of Molecular Evolution, 1999The heterotrophic theory of the origin of life is the only proposal available with experimental support. This comes from the ease of prebiotic synthesis under strongly reducing conditions. The prebiotic synthesis of organic compounds by reduction of CO(2) to monomers used by the first organisms would also be considered an heterotrophic origin ...
Stanley L. Miller, Antonio Lazcano
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Metabolic Pathways of Ochratoxin A
Current Drug Metabolism, 2011Ochratoxin A (OTA) as a carcinogenic of group 2B to humans is produced by various fungi strains as Aspergillus and Penicillium. It is one of the most common contaminant in foodstuff. OTA is nephrotoxic, hepatotoxic, teratogenic, and immunotoxic and is assumed to cause Balkan Endemic Nephropathy (BEN), a chronic kidney disease in humans when it is ...
Zonghui Yuan +6 more
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ACS Synthetic Biology, 2017
Metabolic engineering entails target modification of cell metabolism to maximize the production of a specific compound. For empowering combinatorial optimization in strain engineering, tools and algorithms are needed to efficiently sample the ...
Peng Xu +3 more
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Metabolic engineering entails target modification of cell metabolism to maximize the production of a specific compound. For empowering combinatorial optimization in strain engineering, tools and algorithms are needed to efficiently sample the ...
Peng Xu +3 more
semanticscholar +1 more source
Chromokinetics of metabolic pathways
European Journal of Biochemistry, 2004Some methods to study and intuitively understand steady‐state flows in complicated metabolic pathways are discussed. For this purpose, a suitable decomposition of complex metabolic schemes into smaller subsystems is used. These independent subsystems are then interpreted as basic colors of a chromatic coloring scheme.
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Mass spectrometry-based metabolomics: applications to biomarker and metabolic pathway research.
Biomedical chromotography, 2016Mass spectrometry-based metabolomics has become increasingly popular in molecular medicine. High-definition mass spectrometry (MS), coupled with pattern recognition methods, have been carried out to obtain comprehensive metabolite profiling and metabolic
A. Zhang +4 more
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Endocannabinoid Metabolic Pathways and Enzymes
Current Drug Target -CNS & Neurological Disorders, 2005Endocannabinoids, defined in 1995 as endogenous agonists of cannabinoid receptors, their anabolic and catabolic pathways, and the enzymes involved in these pathways (the "endocannabinoid enzymes"), are the subject of this review. A general strategy seems to apply to the regulation of the levels of the two major endocannabinoids, anandamide and 2 ...
Ligresti A, Cascio MG, Di Marzo V
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