Results 1 to 10 of about 1,277,321 (205)
Metabolic pathway analysis of hyperuricaemia patients with hyperlipidaemia based on high-throughput mass spectrometry: a case‒control study [PDF]
Lipids in Health and Disease, 2022 Background Both hyperuricaemia and hyperlipidaemia are common metabolic diseases that are closely related to each other, and both are independent risk factors for the development of a variety of diseases.
Xue Wei +9 more
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Elementary Vectors and Conformal Sums in Polyhedral Geometry and their Relevance for Metabolic Pathway Analysis. [PDF]
Front Genet, 2016 A fundamental result in metabolic pathway analysis states that every flux mode can be decomposed into a sum of elementary modes. However, only a decomposition without cancelations is biochemically meaningful, since a reversible reaction cannot have ...
Müller S, Regensburger G.
europepmc +4 more sources
Optimization-based framework with flux balance analysis (FBA) and metabolic pathway analysis (MPA) for identifying metabolic objective functions. [PDF]
PLoS Computational BiologyMetabolic network modeling, especially Flux Balance Analysis (FBA), plays a critical role in systems biology by providing insights into cellular behaviors.
Ching-Mei Wen +2 more
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Metabolites, 2022 The mechanism of action of Ardisia japonica in the treatment of immune liver injury was systematically analyzed from the perspective of the biological metabolic network by using non-targeted metabolomics combined with biological network analysis tools. A
Tian Fu +6 more
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Frontiers in Nutrition, 2021 Tomato is one of the world's most consumed vegetables, and thus, various cultivars have been developed. Therefore, metabolic differences and nutrient contents of various tomatoes need to be discovered.
Ha In Mun +6 more
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Pathway analysis of NAD+ metabolism [PDF]
Biochemical Journal, 2011 NAD+ is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD+ is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These include reactions linked to DNA repair and aging.
de Figueiredo, Luis F. +3 more
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Metabolic Pathway Analysis in the Presence of Biological Constraints
Computation, 2021 Metabolic pathway analysis is a key method to study a metabolism in its steady state, and the concept of elementary fluxes (EFs) plays a major role in the analysis of a network in terms of non-decomposable pathways.
Philippe Dague
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Phylogenetic Analysis of Metabolic Pathways [PDF]
Journal of Molecular Evolution, 2001 The information provided by completely sequenced genomes can yield insights into the multi-level organization of organisms and their evolution. At the lowest level of molecular organization individual enzymes are formed, often through assembly of multiple polypeptides. At a higher level, sets of enzymes group into metabolic networks.
C V, Forst, K, Schulten
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Toxins, 2022 Aflatoxins are carcinogenic secondary metabolites produced by several species of Aspergillus, including Aspergillus flavus, an important ear rot pathogen in maize. Most commercial corn hybrids are susceptible to infection by A.
Marilyn L. Warburton +6 more
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Scalable metabolic pathway analysis [PDF]
, 2020 The scope of application of genome-scale constraint-based models (CBMs) of metabolic networks rapidly expands toward multicellular systems. However, comprehensive analysis of CBMs through metabolic pathway analysis remains a major computational challenge because pathway numbers grow combinatorially with model sizes. Here, we define the minimal pathways
Ove Øyås, Jörg Stelling
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