Results 51 to 60 of about 1,277,321 (205)
Frontiers in Microbiology, 2013 Synthetic biology enables metabolic engineering of industrial microbes to synthesize value-added molecules. In this, a major challenge is the efficient redirection of carbon to the desired metabolic pathways.
Ashish eMisra +6 more
doaj +1 more source
Remnants of an ancient metabolism without phosphate [PDF]
, 2017 Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E. +3 more
core +1 more source
Untargeted metabolomics analysis of esophageal squamous cell cancer progression
Journal of Translational Medicine, 2022 90% of esophageal cancer are esophageal squamous cell carcinoma (ESCC) and ESCC has a very poor prognosis and high mortality. Nevertheless, the key metabolic pathways associated with ESCC progression haven’t been revealed yet.
Tao Yang +5 more
doaj +1 more source
Assessing the significance of knockout cascades in metabolic networks
, 2012 Complex networks have been shown to be robust against random structural perturbations, but vulnerable against targeted attacks. Robustness analysis usually simulates the removal of individual or sets of nodes, followed by the assessment of the inflicted ...
Basler, Georg +4 more
core +1 more source
The large-scale organization of metabolic networks [PDF]
, 2000 In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the key role these
Albert, R. +4 more
core +3 more sources
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core +1 more source
Metabolomics analysis: Finding out metabolic building blocks. [PDF]
PLoS ONE, 2017 In this paper we propose a new methodology for the analysis of metabolic networks. We use the notion of strongly connected components of a graph, called in this context metabolic building blocks.
Ricardo Alberich +3 more
doaj +1 more source
Effects of ambient temperature on metabolic syndrome and pathway analysis
环境与职业医学, 2022 BackgroundIn recent years, the incidence of metabolic syndrome (MS) is increasing significantly in China. Some studies have found that temperature is related to single metabolic index, but there is a lack of research on associated mechanism and ...
Jie HU +14 more
doaj +1 more source
Differential Expression Analysis Utilizing Condition-Specific Metabolic Pathways
Metabolites, 2023 Pathway analysis is ubiquitous in biological data analysis due to the ability to integrate small simultaneous changes in functionally related components. While pathways are often defined based on either manual curation or network topological properties, an attractive alternative is to generate pathways around specific functions, in which metabolism can
Gianluca Mattei +4 more
openaire +4 more sources
MetabolitesBackground: Pleioblastus amarus (Keng) Keng f. is widely distributed in southern China and serves as both a medicinal and edible resource. Flavonoids represent the main bioactive compounds in this species, contributing to its antioxidant, anti ...
Yongmei Chen +5 more
doaj +1 more source