Results 61 to 70 of about 1,277,321 (205)

Comprehensive Detection of Genes Causing a Phenotype using Phenotype Sequencing and Pathway Analysis

, 2013
Discovering all the genetic causes of a phenotype is an important goal in functional genomics. In this paper we combine an experimental design for multiple independent detections of the genetic causes of a phenotype, with a high-throughput sequencing ...
Gronenberg, Luisa, Harper, Marc, Lee, Christopher, Liao, James   +3 more
core   +2 more sources

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
core   +2 more sources

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum

mSystems, 2020
In Ralstonia solanacearum, a devastating phytopathogen whose metabolism is poorly understood, we observed that the Entner-Doudoroff (ED) pathway and nonoxidative pentose phosphate pathway (non-OxPPP) bypass glycolysis and OxPPP under glucose oxidation ...
Poonam Jyoti, Manu Shree, Chandrakant Joshi, Tulika Prakash, Suvendra Kumar Ray, Siddhartha Sankar Satapathy, Shyam Kumar Masakapalli   +6 more
doaj   +1 more source

Analysis of complex metabolic behavior through pathway decomposition [PDF]

BMC Systems Biology, 2011
Abstract Background Understanding complex systems through decomposition into simple interacting components is a pervasive paradigm throughout modern science and engineering. For cellular metabolism, complexity can be reduced by decomposition into pathways with particular biochemical functions, and the concept of ...
Ip, K, Colijn, C, Lun, DS
openaire   +5 more sources

PySCeSToolbox: a collection of metabolic pathway analysis tools [PDF]

Bioinformatics, 2017
Abstract Summary PySCeSToolbox is an extension to the Python Simulator for Cellular Systems (PySCeS) that includes tools for performing generalized supply–demand analysis, symbolic metabolic control analysis, and a framework for investigating the kinetic and thermodynamic aspects of enzyme-catalyzed ...
Carl D Christensen, Jan-Hendrik S Hofmeyr, Johann M Rohwer   +2 more
openaire   +2 more sources

Metabolic Properties of Lacticaseibacillus paracasei Zhang ΔpglX during Continuous Passage Culture [PDF]

Shipin Kexue
The aim of this study was to investigate the metabolite changes in Lacticaseibacillus paracasei Zhang ΔpglX, a DNA methyltransferase mutant, after successive passages and to explore the possible mechanism of metabolic regulation during the passage ...
YANG Shuwei, QIAO Jiaqi, ZHANG Wenyi
doaj   +1 more source

PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]

, 2019
Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G, Djukovic, Danijel, Fei, Lin, Iwaki, Takuma, Liles, W. Conrad, Lynn, Jared C, Otinga, Cynthia, Raftery, Daniel, Standage, Stephen W, Stenson, Erin K, Wong, Hector R   +10 more
core   +2 more sources

Causal relationships between blood metabolites and diabetic retinopathy: a two-sample Mendelian randomization study

Frontiers in Endocrinology
BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes, severely affecting patients’ vision and even leading to blindness.
Chongchao Yang, Chongchao Yang, Yan Ma, Yan Ma, Mudi Yao, Qin Jiang, Qin Jiang, Jinsong Xue, Jinsong Xue   +8 more
doaj   +1 more source

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]

, 2008
The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL, De Menezes, MA, Oltvai, ZN, Vazquez, A   +3 more
core   +1 more source