Results 71 to 80 of about 1,277,321 (205)

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Metabolic Pathway Analysis in Cancer

The FASEB Journal, 2013
Reprogramming of cellular metabolism is a hallmark of malignancy. Understanding the metabolic transitions that accompany cellular transformation will lead to new insights into the biological basis of transformation, and may generate new targets for therapy and diagnostic imaging in cancer.
openaire   +1 more source

Pathway analysis of liver metabolism under stressed condition [PDF]

Journal of Theoretical Biology, 2011
Pathway analysis is a useful tool which reveals important metabolic network properties. However, the big challenge is to propose an objective function for estimating active pathways, which represent the actual state of network. In order to provide weight values for all possible pathways within the metabolic network, this study presents different ...
Orman, Mehmet A., Berthiaume, Francois, Androulakis, Ioannis P., Ierapetritou, Marianthi G.   +3 more
openaire   +2 more sources

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

EBioMedicine, 2020
Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC.
Zeribe Chike Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin, Pavlo Holenya, Julia Lochead, Carolina De La Torre, Norbert Gretz, Peter Sajjakulnukit, Li Zhang, Matthew H. Ward, Jens U. Marquardt, Marina Pasca di Magliano, Costas A. Lyssiotis, Jonathan Sleeman, Stefan Wölfl, Matthias Philip Ebert, Christoph Meyer, Ute Hofmann, Steven Dooley   +25 more
doaj   +1 more source

Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome [PDF]

, 2019
The biosynthetic capabilities of microbes underlie their growth and interactions, playing a prominent role in microbial community structure. For large, diverse microbial communities, prediction of these capabilities is limited by uncertainty about ...
Bernstein, David B., Dewhirst, Floyd E., Segrè, Daniel   +2 more
core   +1 more source

Control‐pattern analysis of metabolic pathways [PDF]

European Journal of Biochemistry, 1989
Metabolic control analysis [Kacser and Burns (1973) Symp. Soc. Exp. Biol. 27, 65–104; Heinrich and Rapoport (1974) Eur. J. Biochem. 42, 89–95] leads to a description of the systemic properties of a metabolic system (expressed as control coefficients) in terms of the local kinetic properties of the individual enzyme‐catalyzed reactions (expressed as ...
openaire   +2 more sources

Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility.

PLoS Genetics, 2010
Despite the central role of estrogen exposure in breast and endometrial cancer development and numerous studies of genes in the estrogen metabolic pathway, polymorphisms within the pathway have not been consistently associated with these cancers.
Yen Ling Low, Yuqing Li, Keith Humphreys, Anbupalam Thalamuthu, Yi Li, Hatef Darabi, Sara Wedrén, Carine Bonnard, Kamila Czene, Mark M Iles, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist, Heli Nevanlinna, Per Hall, Edison T Liu, Jianjun Liu   +16 more
doaj   +1 more source

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats [PDF]

, 2016
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome.
A Hagiwara, A Lass, A Shukla, A Subramanian, AM Uhe, B He, BB Albert, C Brandsch, C Chaveroux, CJ Andersen, CW Law, D Eberle, D El Khoury, D Gaidatzis, D Karolchik, D Merico, D Ord, D Tome, DW Gietzen, E Tornberg, G Fromentin, G Sarwar, H Sidransky, HX Yuan, J Cacho, J Schwarz, JI Lee, JL Jewell, JM Beasley, KK Carroll, L Abatangelo, L Noriega-Lopez, LE Matarese, M Friedman, M Shimobayashi, MD Robinson, MD Robinson, ME Ritchie, ML Orgeron, MS Kilberg, N Tachibana, PG Reeves, PM Leung, PM Pereira, R Bourgon, R Hoffenberg, R Hosomi, S Guo, S Madani, S Wen, SM Potter, SN Twigger, T Berry, TG Anthony, V Ranawana, W Gade, W Kang, Y Takahashi   +57 more
core   +2 more sources

Statistical Analysis of Metabolic Pathways of Brain Metabolism at Steady State [PDF]

Annals of Biomedical Engineering, 2007
The estimation of metabolic fluxes for brain metabolism is important, among other things, to test the validity of different hypotheses which have been proposed in the literature. The metabolic model that we propose considers, in addition to the blood compartment, the cytosol, and mitochondria of both astrocyte and neuron, including detailed metabolic ...
R, Occhipinti, M A, Puchowicz, J C, LaManna, E, Somersalo, D, Calvetti   +4 more
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A combined study based on electronic tongue and untargeted metabolomics to reveal taste and metabolite profiles of different varieties wampee (Clausena lansium)

Food Chemistry: X
Wampee is a fruit with a long history of consumption and medicinal value. In this study, four groups of wampee sample from the same nursery were analyzed for systematic analysis of tastes and metabolites using electronic tongue, UHPLC-QTOF-MS/MS and GC ...
Xiaopeng Wu, Xiaoni Guo, Xiao Xu, Xiuju Gao, Chunhua Xu, Xu Wang, Bingqiang Xu   +6 more
doaj   +1 more source