Results 121 to 130 of about 77,361 (253)

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Mitochondrial Dysfunction and Metabolic Indicators in Patients with Drug-Naive First-Episode Schizophrenia: A Case-Control Study

Neuropsychiatric Disease and Treatment
Haoran Chu,* Houming Zhu,* Jiashu Ma, Yijia Jiang, Cuicui Cui, Xianxia Yan, Qin Li, Xinyan Zhang, Diancai Chen, Xianwei Li, Ranran Li Department of Psychiatry, Shandong Mental Health Center, Shandong University, Jinan, People’s Republic of China ...
Chu H, Zhu H, Ma J, Jiang Y, Cui C, Yan X, Li Q, Zhang X, Chen D, Li X, Li R   +10 more
doaj  

Examining Phosphatidylethanol (PEth) Formation Rates Within and Between Subjects in Ex Vivo Whole Blood

Drug Testing and Analysis, EarlyView.
PEth formation rate increased with increasing ethanol concentration with variability between participants but was mostly consistent within‐subject. No relationship was observed between phosphatidylcholine concentrations and PEth formation rates. PEth concentrations should be used to monitor an individual's ethanol use over time, rather than compared ...
Haidyn G. Stark, Jesus J. Sanchez, Nathalie Hill‐Kapturczak, John D. Roache, Brett C. Ginsburg   +4 more
wiley   +1 more source

Correction: Dyńka et al. Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets. <i>Nutrients</i> 2025, <i>17</i>, 965. [PDF]

Nutrients
Dyńka D, Rodzeń Ł, Rodzeń M, Pacholak-Klimas A, Ede G, Sethi S, Łojko D, Bartoń K, Berry K, Deptuła A, Grzywacz Ż, Martin P, Unwin J, Unwin D.   +13 more
europepmc   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Editorial: Ketogenic metabolic therapy as a treatment for mental health disorders

Frontiers in Nutrition
Georgia Ede, Beth A. Zupec-Kania, Susan A. Masino   +2 more
doaj   +1 more source

Revisiting the Management of Treatment-Resistant Depression. [PDF]

Can J Psychiatry
Lee JJ, Blumberger DM.
europepmc   +1 more source

Imaging brain energetics to advance metabolic psychiatry

Neuropsychopharmacology
Naomi L. Gaggi, David T. Liebers
openaire   +3 more sources

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Psychosis in the aftermath of stroke: Pyridoxine-responsive homocystinuria in an adolescent. [PDF]

Indian J Psychiatry
Kannappan R, Jayabalan S, Selvamani I, Nambi S.   +3 more
europepmc   +1 more source