Results 91 to 100 of about 1,074,402 (265)

Chrononutrition Patterns and Nutritional Status Among Working and Non-Working Women Aged 20-60 Years: A Cross-Sectional Study from Surat, India

Journal of Food Innovation, Nutrition, and Environmental Sciences
Chrononutrition aligns eating patterns with circadian rhythms and is crucial for metabolic regulation. This study assessed the association between chrononutrition patterns and nutritional status among working and non-working women in Surat, Gujarat.
Shilpee Agrawal, Umaymah Mohmad Degia
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Perimenopause period and menopause: cardiovascular and metabolic risks

Zaporožskij Medicinskij Žurnal
The number of mature and elderly women is increasing all over the world. According to the World Health Organization, in most countries of the world, the life expectancy of women after the age of 50 ranges from 27 to 32 years.
V. H. Siusiuka, V. A. Vizir, M. Yu. Serhienko, O. V. Demidenko, O. V. Deinichenko   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Respiratory, cardio-metabolic and neurodevelopmental long-term outcomes of moderate to late preterm birth: not just a near term-population. A follow-up study

Frontiers in Medicine
IntroductionModerate-to-late preterm infants constitute the majority within the preterm infant population. Most research on preterm infants has focused on very preterm children, often treating moderate-to-late preterm infants as similar to full-term ...
Patricia Alonso-Lopez, Patricia Alonso-Lopez, Maria Arroyas, Maria Arroyas, Maite Beato, Sara Ruiz-Gonzalez, Sara Ruiz-Gonzalez, Iciar Olabarrieta, Iciar Olabarrieta, Maria Luz Garcia-Garcia, Maria Luz Garcia-Garcia, Maria Luz Garcia-Garcia, Maria Luz Garcia-Garcia   +12 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Novel Metabolic Risk Classification System Incorporating Body Fat, Waist Circumference, and Muscle Strength

Journal of Functional Morphology and Kinesiology
Background: As metabolic diseases continue to rise globally, there is a growing need to improve risk assessment strategies beyond traditional measures such as BMI and waist circumference, which may fail to identify individuals at risk.
Carlos Raúl Robledo-Millán, María Regina Diaz-Domínguez, Ari Evelyn Castañeda-Ramírez, Efrén Quiñones-Lara, Sebastián Valencia-Marín, Ricardo Xopán Suárez-García, Nely Gisela López-Desiderio, Claudio Adrían Ramos-Cortés, Areli Marlene Gaytán Gómez, Juan Manuel Bello-López, Héctor Iván Saldívar-Cerón   +10 more
doaj   +1 more source

A High Incidence of Metabolic Syndrome Traits in Mexicans Points at Obesity-Related Metabolic Dysfunction

Diabetes, Metabolic Syndrome and Obesity, 2021
Omar Yaxmehen Bello-Chavolla,1,2 Arsenio Vargas-Vázquez,1,3,* Neftali Eduardo Antonio-Villa,1,3,* Fabiola Mabel Del Razo-Olvera,1 Daniel Elías-López,1 Carlos A Aguilar-Salinas1,4,5 For the Metabolic Syndrome Study Group1Unidad de ...
Bello-Chavolla OY, Vargas-Vázquez A, Antonio-Villa NE, Del Razo-Olvera FM, Elías-López D, Aguilar-Salinas CA   +5 more
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source