Results 81 to 90 of about 1,074,402 (265)

Determinants of HbA1c Variability Across Clinical Subgroups: When the Same Value Does Not Reflect the Same Biological Risk

Medicina
Background and Objectives: Glycated hemoglobin (HbA1c) is widely used as a marker of long-term glycemic control and metabolic risk, and represents a cornerstone in the diagnosis and management of diabetes mellitus, as endorsed by major international ...
Mihaela Simona Popoviciu, Timea Claudia Ghitea, Carmen Pantis, Roxana Daniela Brata   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Association between the Zhejiang University index and hyperuricemia among adults with type 2 diabetes in China

Frontiers in Endocrinology
PurposeThe Zhejiang University (ZJU) index is an established surrogate marker for metabolic dysfunction-associated steatotic liver disease (MASLD).
Haoxiang Li, Xiaoyan Ma, Xia Deng, Yu Qin, Jiawei Wang, Ling Yang, Guoyue Yuan   +6 more
doaj   +1 more source

Physical activity, BMI and metabolic risk in Portuguese adolescents

Revista Brasileira de Cineantropometria e Desempenho Humano, 2016
It has been reported, in the last decades, a significant decrease in physical activity (PA) levels, with a consequent increase in obesity and metabolic risk factors among youth.
Fernanda Karina dos Santos, Thayse Natacha Queiroz Ferreira Gomes, Michele Caroline de Souza, Raquel Nichele Chaves, Daniel Monteiro de Vilhena Santos, Sara Isabel Sampaio Pereira, Alessandra da Silva Borges, José António Ribeiro Maia   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China

Frontiers in Nutrition
Background and objectiveObesity is a core risk factor for metabolic diseases, and body mass index (BMI) serves as a key tool for assessing obesity. Current internationally adopted BMI standards (such as the WHO universal standard and the Asia-Pacific ...
Dengwen Pang, Meizhu Chen, Chengwen Xiao, Ruijian Zhuang, Chengyu Kong, Mengyuan Xiao   +5 more
doaj   +1 more source

Metabolic syndrome and endometrial cancer risk

Annals of Oncology, 2011
Various studies reported direct associations between endometrial cancer risk and individual components of the metabolic syndrome (MetS), i.e. obesity, diabetes, hypertension, and dyslipidemia, but only a few epidemiological studies considered the association with MetS overall.We analyzed data from a case-control study including 454 women with incident ...
V. Rosato, A. Zucchetto, C. Bosetti, L. Dal Maso, M. Montella, C. Pelucchi, E. Negri, S. Franceschi, C. La Vecchia   +8 more
openaire   +6 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Purpose in Life and Insulin Resistance in a Large Occupational Cohort: Cross-Sectional Associations Using TyG, SPISE-IR, and METS-IR Indices

Diabetology
Background: Insulin resistance (IR) is a key metabolic abnormality underlying type 2 diabetes and cardiometabolic diseases. Although lifestyle and sociodemographic determinants are well described, the role of psychosocial constructs—such as purpose in ...
Pilar García Pertegaz, Pedro Juan Tárraga López, Irene Coll Campayo, Carla Busquets-Cortés, Ángel Arturo López-González, José Ignacio Ramírez-Manent   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source