Results 1 to 10 of about 425,696 (264)
An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib [PDF]
Molecules, 2023 Acalabrutinib, commercially known as Calquence®, is a pharmacological molecule that has robust inhibitory activity against Bruton tyrosine kinase. The medicine in question was carefully developed by the esteemed pharmaceutical company AstraZeneca.
Mohamed W. Attwa +3 more
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Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation [PDF]
Molecules, 2023 Bosutinib (BOS) is FDA approved drug for the treatment of chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).
Mohamed W. Attwa, Mohammed M. Alanazi
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Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes [PDF]
PharmaceuticsBackground: Malaria significantly impacts the health of populations living in poverty and vulnerable conditions. Resistance to current antimalarial drugs remains a major challenge and highlights the urgent need for novel, effective, and safer therapies ...
Debora Bressanim de Aquino Calemi +8 more
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Metabolic Stability and Metabolite Identification of N-Ethyl Pentedrone Using Rat, Mouse and Human Liver Microsomes [PDF]
PharmaceuticsNew Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications of traditional drugs. These molecules represent a public health problem since information about their metabolites and toxicity is poorly ...
Alexandre Barcia Godoi +5 more
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Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening [PDF]
Frontiers in ChemistryIntroductionCEP-37440 was synthesized and supplied by the research and development division of Teva Branded Pharmaceutical Products (West Chester, PA, United States). CEP-37440 represents a newly developed compound that exhibits selectivity inhibition of
Mohamed W. Attwa +3 more
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CYP2C9 mediates the herb-drug interaction of curcumin with naproxen in rats [PDF]
Acta Poloniae Pharmaceutica, 2023 Both curcumin and naproxen possess the activity of pain relief, which makes it possible to co-administrate these drugs in the same prescription. This study aimed to assess the potential pharmacokinetic interaction of naproxen with curcumin in rats ...
Yongjun Qiu, Sujun Huang, Minfang Zhu
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Frontiers in Pharmacology, 2023 Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammatory and antitumor effects.
Yingzi Li +8 more
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Pharmaceutics, 2023 Alectinib, also known as Alecensa®, is prescribed for the therapeutic treatment of individuals diagnosed with metastatic non-small cell lung cancer (NSCLC) who have a specific genetic mutation referred to as anaplastic lymphoma kinase (ALK) positivity ...
Mohamed W. Attwa +3 more
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Molecules, 2022 The purpose of this study was to identify potential metabolic pathways and metabolites of OJT007, a methionine aminopeptidase 1 (MetAP1) inhibitor. OJT007 is a novel drug with potent antiproliferative effects against Leishmania Major.
Maria Eugenia Rincon Nigro +6 more
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Molecules, 2023 Selpercatinib (SLP; brand name Retevmo®) is a selective and potent RE arranged during transfection (RET) inhibitor. On 21 September 2022, the FDA granted regular approval to SLP (Retevmo, Eli Lilly, and Company).
Mohamed W. Attwa +4 more
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