Results 141 to 150 of about 425,696 (264)

Glial Plasticity and Metabolic Stability After Knockdown of Astrocytic Cx43 in the Dorsal Vagal Complex. [PDF]

Cells
Barbot M, Lebrun B, Barbouche R, Gaigé S, Tonetto A, Abysique A, Troadec JD.   +6 more
europepmc   +1 more source

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability. [PDF]

Acta Pharm Sin B, 2023
Sang YL, Pannecouque C, De Clercq E, Wang S, Chen FE.   +4 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Controlling metabolic stability of food microbiome for stable indigenous liquor fermentation. [PDF]

NPJ Biofilms Microbiomes
Tan Y, Zhu Y, Wijffels RH, Zhang H, Scott WT, Xu Y, Martins Dos Santos V.   +6 more
europepmc   +1 more source

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D₃ and Identification of Their Metabolites. [PDF]

Biomolecules, 2023
Mizumoto Y, Sakamoto R, Iijima K, Nakaya N, Odagi M, Tera M, Hirokawa T, Sakaki T, Yasuda K, Nagasawa K.   +9 more
europepmc   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Development and validation of a UPLC-MS/MS method for the quantification of asciminib and its pharmacokinetic interaction and metabolic stability with shikonin. [PDF]

BMC Pharmacol Toxicol
Zhou C, Xia H, Hu Y, Chen X, Zou Q, Xu X, Jiang ZL.   +6 more
europepmc   +1 more source

Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif. [PDF]

J Med Chem, 2023
Bassetto M, Zaluski J, Li B, Zhang J, Badiee M, Kiser PD, Tochtrop GP.   +6 more
europepmc   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

HyperPhS: a pharmacophore-guided multimodal representation framework for metabolic stability prediction through contrastive hypergraph learning. [PDF]

Bioinformatics
Liu X, Zhang N, Kang C, Ai C, Yang H, Tang J, Guo F.   +6 more
europepmc   +1 more source