Results 21 to 30 of about 425,696 (264)
Molecules, 2015 A series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids.
Beata Żołnowska +7 more
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Separations, 2023 Savolitinib (Orpathys®), was developed by (HUTCHMED (Shanghai, China) and, AstraZeneca (Gaithersburg, Maryland, USA), is an inhibitor of the c-Met receptor tyrosine kinase that is orally bioavailable.
Mohamed W. Attwa +3 more
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Separations, 2023 Capmatinib (CMB) is an orally bioavailable mesenchymal–epithelial transition (MET) inhibitor approved by the US-FDA to treat metastatic non-small cell lung cancer (NSCLC) patients, with MET exon 14 skipping mutation.
Mohamed W. Attwa +3 more
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Stabilizing selection and metabolism [PDF]
Heredity, 1988 This paper attempts to provide a biochemical explanation for selection against extreme phenotypes. From current ideas on the analysis of metabolic control, it is argued that, on average, most mutations will reduce flux through metabolic pathways and change substrate pool concentrations in an arbitrary direction.
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A highly sensitive LC-MS/MS method to determine novel Bruton's tyrosine kinase inhibitor spebrutinib: application to metabolic stability evaluation [PDF]
Royal Society Open Science, 2019 Spebrutinib (SBT) is a Bruton's tyrosine kinase inhibitor. SBT is currently in phase II and phase I clinical trials for the management of rheumatoid arthritis and chronic lymphocytic leukaemia, respectively.
Ali S. Abdelhameed +3 more
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Separations, 2023 Fenebrutinib (GDC-0853; FNB) is an oral small molecule that was developed by Roche Pharmaceuticals to slow multiple sclerosis progression. FNB is a reversible bruton tyrosine kinase (BTK) inhibitor, which showed the maximum potency of BTK inhibitors in ...
Mohamed W. Attwa +4 more
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Connecting Hsp70, sphingolipid metabolism and lysosomal stability [PDF]
Cell Cycle, 2010 Heat shock protein 70 (Hsp70) is an evolutionary highly conserved molecular chaperone. Upon cancer-associated translocation to the lysosomal compartment, it promotes cell survival by inhibiting lysosomal membrane permeabilization, a hallmark of stress-induced death. We have recently shown that Hsp70 stabilizes lysosomes by binding to the endo-lysosomal
Nikolaj H T, Petersen +3 more
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Pharmaceutics, 2022 Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive activities of a cyclic selenoanhydride and of a series of selenoesters.
Małgorzata Anna Marć +6 more
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Epigenetic and Genetic Integrity, Metabolic Stability, and Field Performance of Cryopreserved Plants
Plants, 2021 Cryopreservation is considered an ideal strategy for the long-term preservation of plant genetic resources. Significant progress was achieved over the past several decades, resulting in the successful cryopreservation of the genetic resources of diverse ...
Min-Rui Wang +7 more
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Molecules, 2016 A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid.
Beata Żołnowska +9 more
doaj +1 more source