Results 211 to 220 of about 824,950 (297)

Editorial: Natural bioactives: a promising avenue for metabolic syndrome therapy. [PDF]

Front Nutr
Machado M, Gouvinhas I, Silva S, Costa EM.   +3 more
europepmc   +1 more source

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, EarlyView.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

The Effect of Metabolic Syndrome on Alzheimer's Disease: Physical Activity as a Preventive and Therapeutic Measure. [PDF]

Brain Sci
Ramírez Hernández E, Netzahualcoyotzi C, Hurtado-Alvarado G, Sánchez JL, Pereyra Morales A, Arredondo-Zamarripa D, Hernández-Zimbrón LF, Papy-Garcia D, Guevara J, Gutiérrez Ponce N, Gomez-Henao W, Garfias Y, Ortiz Chavez G, Zenteno E.   +13 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Challenges and knowledge gaps in sex differences in cardio-kidney-metabolic syndrome across the lifespan. [PDF]

Biol Sex Differ
de Souza AMA, Kautzky-Willer A, Romero DG, Yanes Cardozo LL, Ahmed SB, Rezq S.   +5 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Application of Artificial Intelligence in the Diagnosis, Prediction, and Management of Metabolic Syndrome: A Systematic Review. [PDF]

Health Sci Rep
Esmailzadeh A, Norouzkhani N, Sezavar Dokhtfaroughi S, Rasoulian A, Mazaheri Habibi MR.   +4 more
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Optimizing Care in Cardiovascular-Kidney-Metabolic Syndrome: Registry Data From the Cardiometabolic Center Alliance. [PDF]

Circ Popul Health Outcomes
Neeland IJ, Magwire ML, Kwun A, Aistrope DS, Andaya EAK, Bashall A, Benziger CP, De Albuquerque Rocha N, Butler J, Davis L, Denicola D, Eckel RH, Gosch K, Harness L, Helms AR, Iluyomade A, Miller KA, Gianos E, Donahoe S, Patel S, Plutzky J, Stafos A, Sauer AJ, Rajagopalan S, Kosiborod MN.   +24 more
europepmc   +1 more source

The metabolic syndrome and menopause

Journal of Mid-life Health, 2018
Ranu Patni, Annil Mahajan
openaire   +3 more sources