Results 191 to 200 of about 774,651 (247)

ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

J Am Soc Nephrol
Bansal N, Bjornstad P, Bress AP, Chang TI, Cheng X, Estrella MM, Go AS, Mottl AK, Navaneethan SD, Neuen BL, Rifkin BS, Zuber K, Chang AR, on behalf of the ASN Kidney Health Guidance Workgroup on the Cardiovascular-Kidney-Metabolic Syndrome.   +13 more
europepmc   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Pharmacomicrobiomics in metabolic syndrome and type 2 diabetes: the microbiome-drug-host triad. [PDF]

Front Pharmacol
Strilić D, Stanimirov B, Pavlović N, Lazarević S, Mikov M, Stanivuković T, Đanić M.   +6 more
europepmc   +1 more source

A Facial Foundation Model for Clinical Biomarker Prediction and Real‐World Mobile Deployment

Advanced Science, EarlyView.
MedicalFaceFound is a facial foundation model developed through three‐stage progressive pre‐training, adapting representations from general vision to facial structure and clinical phenotypes. Using a single facial image, it estimates 62 biomarkers across multiple physiological systems and supports downstream risk prediction for cardiovascular ...
Tingfeng Xu, Huixuan Xu, Li Lin, Fei Wang, Yaodong Ding, Shuangqiao Liao, Xingyu Chen, Jichen Wen, Hongqiang Zhao, Jing Hao, Weixiang Zhao, Gong Zhang, Shiguang Shan, Yong Zeng, Hu Han, Minxian Wang   +15 more
wiley   +1 more source

Occupational Organophosphorus Pesticide Exposure and Metabolic Syndrome: Implications of PPARγ. [PDF]

Toxics
Sakr S, Eldaly MM, Elshamy RA, Almadani N, Nofal HA, Hammad SA, Eldesoqui M, Soliman WI.   +7 more
europepmc   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Associations of Cardiovascular-Kidney-Metabolic Syndrome With All-Cause and Cardiovascular Death and the Progression of Cardiovascular-Kidney-Metabolic Syndrome Among Hong Kong Chinese People Over 2 Decades. [PDF]

J Am Heart Assoc
Li L, Lui DT, Fong CH, Mak JH, Cheung CY, Xu A, Tan KC, Tse HF, Woo J, Lam TH, Woo YC, Cheung BM, Lam KS, Lee CH.   +13 more
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Is Acanthosis Nigricans a Marker for Metabolic Syndrome? A Systematic Review. [PDF]

Am J Clin Dermatol
Gillespie J, Roland-McGowan J, Diehl K, Latour E, Nelson J, Tobey T, Paz-Munoz E, Champelli K, Joyce M, Norris K, Khare S, Bonazzola M, Wisco O, Ortega-Loayza A, Fan G, Leachman S.   +15 more
europepmc   +1 more source