Results 41 to 50 of about 454,613 (260)

Is Metabolic Syndrome X an Inflammatory Condition?

Experimental Biology and Medicine, 2002
It is suggested that metabolic syndrome X is a low-grade systemic Inflammatory condition.
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Molecules
A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome.
Young Jin Jung, Narges Hosseininasab, Jungjin Park, Soonsil Hyun, Jae-Kyung Jung, Jae-Hwan Kwak   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Central Retinal Artery Occlusion in a Patient with Metabolic Syndrome X

Journal of Ophthalmic & Vision Research, 2010
Purpose: To report a case of central retinal artery occlusion (CRAO) in a patient with metabolic syndrome X. Case Report: A 64 year-old-man presented with abrupt, painless, and severe loss of vision in his left eye.
Sonja Predrag Cekić, Tatjana Petković, Gordana Ljubomir Stanković-Babić, Jovica Mile Mršić   +3 more
doaj  

Efeitos de curto prazo de um programa de atividade física moderada em pacientes com síndrome metabólica

Einstein (São Paulo)
OBJETIVO: Avaliar se um programa de exercícios de intensidade moderada por um pequeno período pode alterar os parâmetros inflamatórios e melhorar os diferentes componentes da síndrome metabólica em pacientes sedentários.
Caroline Macoris Colombo, Rafael Michel de Macedo, Miguel Morita Fernandes-Silva, Alexandra Moro Caporal, Andréa Emilia Stinghen, Costantino Roberto Costantini, Cristina Pellegrino Baena, Luiz Cesar Guarita-Souza, José Rocha Faria-Neto   +8 more
doaj   +1 more source

The five-year survival of patients with various components of metabolic syndrome after Q-myocardial infarction

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
Introduction. According to clinical studies the presence of metabolic syndrome contributes significant increase in the level of early hospital mortality and impairs remote prognosis and survival of patients after myocardial infarction [5,6].The major ...
N. S. Mikhaylovska
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source