Results 61 to 70 of about 429,140 (308)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Relationship Between Long Working Hours and Metabolic Syndrome Among Korean Workers

Asian Nursing Research, 2017
Purpose: This study investigated gender differences in the relationship between long working hours and metabolic syndrome. Methods: Data based on the Sixth National Health and Nutrition Examination Survey (2014) pertaining to a total of 1,145 paid ...
Jungok Yu, RN, PhD
doaj   +1 more source

Comparison of the established definition criteria for diagnosing metabolic syndrome between overweight and obese children in Vojvodina [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. Metabolic syndrome is a clinical term which encompasses obesity, insulin resistance, dyslipidemia, hypertension, as well as an increased risk of the development of diabetes mellitus type 2 and cardiovascular disorders in early ...
Vorgučin Ivana, Vlaški Jovan, Naumović Nada, Katanić Dragan   +3 more
doaj   +1 more source

Body composition in patients with early rheumatoid arthritis

Научно-практическая ревматология, 2021
Aim of the study was to clarify the body composition in patients with early rheumatoid arthritis before starting therapy with synthetic basic anti-inflammatory drugs, genetically engineered biological drugs and glucocorticoids using dual-energy X-ray ...
Yu. N. Gorbunova, L. V. Kondratyeva, T. V. Popkova, N. V. Demin, A. V. Smirnov, E. L. Nasonov   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors [PDF]

, 2013
The electronic version of this article is the complete one and can be found online at: http://www.cardiab.com/content/12/1/93. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.
Veerapol Kukongviriyapan, Vichai Senthong, Suphawadee Phababpha, Upa Kukongviriyapan, Chatri Settasatian, Pyatat Tatsanavivat, Senggunprai, L, Nantarat Komanasin, Poungrat Pakdeechote, Pakdeechote, P, Komanasin, N, Tatsanavivat, P, Nongnuch Settasatian, Senthong, V, Phongsak Intharaphet, Stephen E Greenwald, Settasatian, C, Intharaphet, P, Kukongviriyapan, V, Kukongviriyapan, U, Phababpha, S, Greenwald, SE, Laddawan Senggunprai, Settasatian, N   +23 more
core   +1 more source

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Molecules
A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome.
Young Jin Jung, Narges Hosseininasab, Jungjin Park, Soonsil Hyun, Jae-Kyung Jung, Jae-Hwan Kwak   +5 more
doaj   +1 more source

Prevalence of metabolic syndrome in mainland china: a meta-analysis of published studies

BMC Public Health, 2016
Background Metabolic syndrome (MS) comprises a set of conditions that are risk factors for cardiovascular diseases and diabetes. Numerous epidemiological studies on MS have been conducted, but there has not been a systematic analysis of the prevalence of
Ri Li, Wenchen Li, Zhijun Lun, Huiping Zhang, Zhi Sun, Joseph Sam Kanu, Shuang Qiu, Yi Cheng, Yawen Liu   +8 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source