Results 61 to 70 of about 7,834,690 (307)

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Molecules
A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome.
Young Jin Jung, Narges Hosseininasab, Jungjin Park, Soonsil Hyun, Jae-Kyung Jung, Jae-Hwan Kwak   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Peroxisome proliferator-activated receptors and the metabolic syndrome.

, 2008
The prevalence of the metabolic syndrome is rapidly increasing. This syndrome is characterized by metabolic disturbances, such as abnormal lipid and carbohydrate metabolism and a low-grade inflammatory state.
Popeijus, H.E., Bragt, M.C.E.
core   +1 more source

Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study [PDF]

, 2017
BACKGROUND: In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between
최규헌, 김영리, 유태현, 한승혁   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Central Retinal Artery Occlusion in a Patient with Metabolic Syndrome X

Journal of Ophthalmic & Vision Research, 2010
Purpose: To report a case of central retinal artery occlusion (CRAO) in a patient with metabolic syndrome X. Case Report: A 64 year-old-man presented with abrupt, painless, and severe loss of vision in his left eye.
Sonja Predrag Cekić, Tatjana Petković, Gordana Ljubomir Stanković-Babić, Jovica Mile Mršić   +3 more
doaj  

Efeitos de curto prazo de um programa de atividade física moderada em pacientes com síndrome metabólica

Einstein (São Paulo)
OBJETIVO: Avaliar se um programa de exercícios de intensidade moderada por um pequeno período pode alterar os parâmetros inflamatórios e melhorar os diferentes componentes da síndrome metabólica em pacientes sedentários.
Caroline Macoris Colombo, Rafael Michel de Macedo, Miguel Morita Fernandes-Silva, Alexandra Moro Caporal, Andréa Emilia Stinghen, Costantino Roberto Costantini, Cristina Pellegrino Baena, Luiz Cesar Guarita-Souza, José Rocha Faria-Neto   +8 more
doaj   +1 more source

The five-year survival of patients with various components of metabolic syndrome after Q-myocardial infarction

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
Introduction. According to clinical studies the presence of metabolic syndrome contributes significant increase in the level of early hospital mortality and impairs remote prognosis and survival of patients after myocardial infarction [5,6].The major ...
N. S. Mikhaylovska
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source