Results 91 to 100 of about 3,023,997 (318)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Different trajectories of exosomatic energy metabolism for Brazil, Chile and Venezuela: using the MSIASM approach [PDF]

Economic development goes hand in hand with an increase in the consumption of natural resources. Some analysts use material flows to describe such relationship [Eurostat 2001, Weisz et al., 2006], or exergy [Ayres et al., 2003].
Nina Eisenmenger, Jesus Ramos-Martín, Heinz Schandl   +2 more
core  

Metabolite profile of treatment-naive metabolic syndrome subjects in relation to cardiovascular disease risk

, 2021
Metabolic syndrome (MetSyn) is an important risk factor for type 2 diabetes and cardiovascular diseases (CVD). This study aimed to find distinct plasma metabolite profiles between insulin-resistant and non-insulin resistant subjects with MetSyn and ...
Pieter F. de Groot, ter Horst, Kasper W., Hartstra, Annick V., Soeters, Maarten R., Kristien E. C. Bouter, Nicolien C. de Clercq, Kootte, Ruud S., Nieuwdorp, Max, Kasper W. ter Horst, Mariette T. Ackermans, Annefleur M. Koopen, Serlie, Mireille J., Koopen, Annefleur M., van Raalte, Daniel H., Mark Davids, Davids, Mark, Albert K. Groen, Warmbrunn, Moritz V., Ruud S. Kootte, Bouter, Kristien E. C., Max Nieuwdorp, de Groot, Pieter F., Annick V. Hartstra, Mireille J. Serlie, Moritz V. Warmbrunn, Ackermans, Mariette T., de Clercq, Nicolien C., Groen, Albert K., Daniel H. van Raalte, Maarten R. Soeters   +29 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

METABOLISM IN DIABETES [PDF]

JAMA: The Journal of the American Medical Association, 1909
In my student days in Germany during the winter semester of 1898, I visited the laboratory of the botanical garden of Munich to call on Oscar Loew, who had some time before been assistant to Dr. R. Ogden Doremus in the City College of New York. Loew showed me how he was passing the vapor of methyl-alcohol (CH3CH) over hot oxidized wire gauze and ...
openaire   +1 more source

Altered propionate metabolism contributes to tumour progression and aggressiveness

, 2022
The alteration of metabolic pathways is a critical strategy for cancer cells to attain the traits necessary for metastasis in disease progression. Here, we find that dysregulation of propionate metabolism produces a pro-aggressive signature in breast and
Gomes, AP, Mullarky, E, Han, J, Rosenzweig, A, Elia, I, Low, V, Drapela, S, Ilter, D, Schild, T, Broekaert, D   +9 more
core   +1 more source

Imidazole Propionate Induces Kidney Damage by Activating the ROS-NLRP3 Signaling Pathway Through mTOR Inhibition of Autophagy in Renal Tubular Epithelial Cells

Mediators of Inflammation
L-Histidine, a parent structure of environmental contaminants (e.g., pesticides and preservatives), may undergo bioaccumulation through the food chain and be metabolized by the gut microbiota into deleterious compounds, ultimately compromising human ...
Chen Zeng, Yu-Ru Xiao, Si-Qing Li, Man Guo, Qi Wu, Yi-Meng He, Yu-Fan Zhang, Xiao-Zhen Tan, Yong Xu, Fang-Yuan Teng   +9 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient Inadequacy Rates Among Japanese Adolescents Aged 10–14: Cross-Sectional Pooled Analysis From 2018 to 2023 (NICE EVIDENCE Study 5)

Journal of Nutrition and Metabolism
This study aimed to describe the demographics, nutrient and food group intakes, and adherence to dietary guidelines among Japanese adolescents aged 10–14 years.
Efrem d’Avila Ferreira, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Izumi Ikeda, Risa Igarashi Matsumoto, Mizuki Takeuchi, Mariko Hatta, Chika Horikawa, Laymon Khin, Hajime Ishiguro, Kazuya Fujihara, Yohei Ogawa, Hirohito Sone   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source