Results 81 to 90 of about 3,023,997 (318)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Evaluation of Compliance With International Guidelines During the Follow-Up of Hypoparathyroidism
International Journal of EndocrinologyConclusion: In our research, it was discovered that patients with hypoparathyroidism had low compliance rates with the guidelines. We believe that the cause of this is the inability to provide the patients with enough time in intense polyclinic ...
Beril Turan Erdogan +7 more
doaj +1 more source
Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy
Eurasian Journal of Medicine, 2019 Objective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes.
Eser Tasci +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Oncology Therapeutics Targeting the Metabolism of Amino Acids
, 2020 Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion.
Nefertiti Muhammad +2 more
core +1 more source
Lipid Metabolism in Inflammation and Immune Function
, 2022 Lipid metabolism plays an essential role in modulating inflammation within the context of acute and chronic diseases [...
Catherine J. Andersen
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Visceral adipose tissue (VAT) dysfunction has been recently recognized as a potential contributor to the development of Alzheimer’s disease (AD). This study aimed to explore the relationship between VAT metabolism and cerebral glucose metabolism in
Ji Sun Lim +4 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Regulatory T cell metabolism in atherosclerosis
, 2020 Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a ...
Lutgens, Esther +3 more
core +1 more source