Results 61 to 70 of about 2,075,060 (269)

Evaluation of Compliance With International Guidelines During the Follow-Up of Hypoparathyroidism

International Journal of Endocrinology
Conclusion: In our research, it was discovered that patients with hypoparathyroidism had low compliance rates with the guidelines. We believe that the cause of this is the inability to provide the patients with enough time in intense polyclinic ...
Beril Turan Erdogan, Sefika Burcak Polat, Caglar Keskin, Narin Nasiroglu İmga, Didem Ozdemir, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

METABOLISM IN DIABETES [PDF]

JAMA: The Journal of the American Medical Association, 1909
In my student days in Germany during the winter semester of 1898, I visited the laboratory of the botanical garden of Munich to call on Oscar Loew, who had some time before been assistant to Dr. R. Ogden Doremus in the City College of New York. Loew showed me how he was passing the vapor of methyl-alcohol (CH3CH) over hot oxidized wire gauze and ...
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Imidazole Propionate Induces Kidney Damage by Activating the ROS-NLRP3 Signaling Pathway Through mTOR Inhibition of Autophagy in Renal Tubular Epithelial Cells

Mediators of Inflammation
L-Histidine, a parent structure of environmental contaminants (e.g., pesticides and preservatives), may undergo bioaccumulation through the food chain and be metabolized by the gut microbiota into deleterious compounds, ultimately compromising human ...
Chen Zeng, Yu-Ru Xiao, Si-Qing Li, Man Guo, Qi Wu, Yi-Meng He, Yu-Fan Zhang, Xiao-Zhen Tan, Yong Xu, Fang-Yuan Teng   +9 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Nutrient Inadequacy Rates Among Japanese Adolescents Aged 10–14: Cross-Sectional Pooled Analysis From 2018 to 2023 (NICE EVIDENCE Study 5)

Journal of Nutrition and Metabolism
This study aimed to describe the demographics, nutrient and food group intakes, and adherence to dietary guidelines among Japanese adolescents aged 10–14 years.
Efrem d’Avila Ferreira, Sakiko Yoshizawa Morikawa, Yasunaga Takeda, Izumi Ikeda, Risa Igarashi Matsumoto, Mizuki Takeuchi, Mariko Hatta, Chika Horikawa, Laymon Khin, Hajime Ishiguro, Kazuya Fujihara, Yohei Ogawa, Hirohito Sone   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Treated with Metformin and SGLT-2 Inhibitors (SO GOOD Study)

Journal of Diabetes Research
Background. We aimed to compare efficacy and safety between gemigliptin add-on and escalation of the metformin dose in patients with inadequately controlled type 2 diabetes mellitus (T2DM) despite treatment with metformin and SGLT2 inhibitors.
Hae Jin Kim, Jung Hyun Noh, Min Kyong Moon, Sung Hee Choi, Seung-Hyun Ko, Eun-Jung Rhee, Kyu Yeon Hur, In-Kyung Jeong   +7 more
doaj   +1 more source