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Understanding and Classifying Metabolite Space and Metabolite-Likeness [PDF]
PLoS ONE, 2011 While the entirety of 'Chemical Space' is huge (and assumed to contain between 10(63) and 10(200) 'small molecules'), distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolites, defined as 'naturally occurring' products of an
Peironcely, Miguel J.E. +4 more
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Transportable hyperpolarized metabolites [PDF]
Nature Communications, 2017 AbstractNuclear spin hyperpolarization of 13C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization ...
Basile Vuichoud +10 more
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Metabolites, 2011 Volatile organic compounds (volatiles) comprise a chemically diverse class of low molecular weight organic compounds having an appreciable vapor pressure under ambient conditions. Volatiles produced by plants attract pollinators and seed dispersers, and provide defense against pests and pathogens.
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Metabolite medicine offers a path beyond lists of metabolites [PDF]
Communications Chemistry, 2021 Aimed to decipher the levels of metabolites, metabolomics can now advance to unraveling their functionalities in various contexts. Here, the authors present the metabolite medicine concept, integrating classical metabolomics methods with advanced computational and structural tools to facilitate functional studies.
Shira Shaham-Niv +2 more
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Focus Issue on Metabolism: Metabolites, Metabolites Everywhere [PDF]
Plant Physiology, 2015 Metabolic studies have arguably been conducted since the 13th century with Ibn al-Nafis stating that “the body and its parts are in a continuous state of dissolution and nourishment, so they are inevitably undergoing permanent change” ([Mahdi, 1974][1]).
Eran Pichersky, Alisdair R. Fernie
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Bignoniaceae Metabolites as Semiochemicals [PDF]
Molecules, 2010 Members of the family Bignoniaceae are mostly found in tropical and neo-tropical regions in America, Asia and Africa, although some of them are cultivated in other regions as ornamentals. Species belonging to this family have been extensively studied in regard to their pharmacological properties (as extracts and isolated compounds).
Castillo, Lucia, Rossini, Carmen
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A Metabolite of ‘Carbromal’ [PDF]
Nature, 1960 ‘CARBROMAL’ (α-bromo diethylacetyl urea) is in widespread use as a sedative and hypnotic. None of its metabolites has, as yet, been fully characterized.
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Experimental Biology and Medicine, 1951 SummaryFollowing injection of I131 labeled L-thyroxine into intact and thyroid-ectomized mice and intact rats, tissues and excreta were investigated by radioautography of paper chromatograms of their butanol extracts. Four substances, namely thyroxine, iodide and two unidentified iodine containing substances referred to as compounds Nos.
Jack Gross, C. P. Leblond
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, 2012 Abstract This chapter provides an overview of recent research on the effects of genotype fruit development and growing conditions on the synthesis and concentrations of the following metabolites in pepper (Capsicum spp.): antioxidants, carotenoids, phenolic compounds, capsaicinoids, flavonoids and vitamin C.
Frary, Amy, Frary, Anne
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, 2008 Metabolites are the products of enzyme-catalyzed reactions that occur naturally within living cells. Metabolites are synthesized by the cell for the purpose of performing a useful, if not indispensable, function in the maintenance and survival of the cells by, for example, contributing to its infrastructure or energy requirements.
Roessner, Ute, Beckles, Diane M
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