Results 1 to 10 of about 427,420 (100)

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer’s disease based on multi-platform metabolomics analyses

Frontiers in Pharmacology, 2022
Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat Alzheimer’s disease (AD). However, the effect and its molecular mechanism are not elucidated clear.
Hui Wang, Jian-Ying Dai, Yu-Zhen He, Zhe-Wei Xia, Xiao-Fei Chen, Zhan-Ying Hong, Yi-Feng Chai   +6 more
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Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma

Metabolites, 2023
The untargeted approach to mass spectrometry-based metabolomics has a wide potential to investigate health and disease states, identify new biomarkers for diseases, and elucidate metabolic pathways.
Michał Kaczmarek, Nanyun Zhang, Ludmila Buzhansky, Sharon Gilead, Ehud Gazit   +4 more
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New Insights into Molecular Mechanisms Mediating Adaptation to Exercise; A Review Focusing on Mitochondrial Biogenesis, Mitochondrial Function, Mitophagy and Autophagy

Cells, 2021
Exercise itself is fundamental for good health, and when practiced regularly confers a myriad of metabolic benefits in a range of tissues. These benefits are mediated by a range of adaptive responses in a coordinated, multi-organ manner.
Fiona Louise Roberts, Greg Robert Markby
doaj   +1 more source

Zhi-Zi-Chi Decoction Reverses Depressive Behaviors in CUMS Rats by Reducing Oxidative Stress Injury Via Regulating GSH/GSSG Pathway

Frontiers in Pharmacology, 2022
Depression is one of the main diseases that lead to disability and loss of ability to work. As a traditional Chinese medicine, Zhi-zi-chi decoction is utilized to regulate and improve depression.
Yin Zhang, Yin Zhang, Yin Zhang, Yi-Chao Fang, Yi-Chao Fang, Li-Xun Cui, Li-Xun Cui, Yue-Tong Jiang, Yue-Tong Jiang, Yu-Sha Luo, Yu-Sha Luo, Wen Zhang, Wen Zhang, De-Xun Yu, De-Xun Yu, Jun Wen, Jun Wen, Ting-Ting Zhou, Ting-Ting Zhou   +18 more
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Saliva metabolome alterations after acute stress

Scientific Reports, 2022
Major stress has systemic effects on the body that can have adverse consequences for physical and mental health. However, the molecular basis of these damaging effects remains incompletely understood.
Liat Morgan, Rune Isak Dupont Birkler, Shira Shaham-Niv, Yonghui Dong, Tal Wachsman, Lior Carmi, Boris Yakobson, Lihi Adler-Abramovich, Hagit Cohen, Joseph Zohar, Melissa Bateson, Ehud Gazit   +11 more
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Screening of immune cell activators from Astragali Radix using a comprehensive two-dimensional NK-92MI cell membrane chromatography/C18 column/time-of-flight mass spectrometry system

Journal of Pharmaceutical Analysis, 2022
Astragali Radix (AR) is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer (NK) cells.
Xinyi Chai, Yanqiu Gu, Lei Lv, Chun Chen, Fei Feng, Yan Cao, Yue Liu, Zhenyu Zhu, Zhanying Hong, Yifeng Chai, Xiaofei Chen   +10 more
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Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells

Frontiers in Pharmacology, 2021
Zhi-zi-chi Decoction (ZZCD), composed of Fructus Gardeniae (Zhizi in Chinese, ZZ in brief) and Semen sojae praeparatum (Dandouchi in Chinese, DDC in brief), has been used as a drug therapy for depression for thousands of years in China.
Yin Zhang, Yin Zhang, Yusha Luo, Yusha Luo, Dongqi Zhang, Bo Pang, Jun Wen, Jun Wen, Tingting Zhou, Tingting Zhou   +9 more
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Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies

Molecules, 2017
Chlorin e6-C15-monomethyl ester (CMME) is a novel photosensitizer, which is synthetized from the degradation products of silkworm excrement. Preclinical studies on the promising photosensitizer CMME are necessary to determine its therapeutic efficacy and
Xiuxiu Li, Jun Wen, Jingjing Jiang, Xin Zhao, Tingting Zhou, Guorong Fan   +5 more
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Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

Molecular Metabolism, 2023
Objective: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively.
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen   +9 more
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Enantioselective Separation of Mirtazapine and Its Metabolites by Capillary Electrophoresis with Acetonitrile Field-Amplified Sample Stacking and Its Application

Molecules, 2014
A simple, rapid and sensitive chiral capillary zone electrophoresis coupled with acetonitrile-field-amplified sample stacking method was developed that allows the simultaneous enantioselective separation of the mirtazapine, N-demethylmirtazapine, 8 ...
Jun Wen, Wen-Ting Zhang, Wei-Qun Cao, Ji Li, Fang-Yuan Gao, Nan Yang, Guo-Rong Fan   +6 more
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