Results 1 to 10 of about 985,469 (331)

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer’s disease based on multi-platform metabolomics analyses

Frontiers in Pharmacology, 2022
Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat Alzheimer’s disease (AD). However, the effect and its molecular mechanism are not elucidated clear.
Hui Wang, Jian-Ying Dai, Yu-Zhen He, Zhe-Wei Xia, Xiao-Fei Chen, Zhan-Ying Hong, Yi-Feng Chai   +6 more
doaj   +1 more source

Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma

Metabolites, 2023
The untargeted approach to mass spectrometry-based metabolomics has a wide potential to investigate health and disease states, identify new biomarkers for diseases, and elucidate metabolic pathways.
Michał Kaczmarek, Nanyun Zhang, Ludmila Buzhansky, Sharon Gilead, Ehud Gazit   +4 more
doaj   +1 more source

New Insights into Molecular Mechanisms Mediating Adaptation to Exercise; A Review Focusing on Mitochondrial Biogenesis, Mitochondrial Function, Mitophagy and Autophagy

Cells, 2021
Exercise itself is fundamental for good health, and when practiced regularly confers a myriad of metabolic benefits in a range of tissues. These benefits are mediated by a range of adaptive responses in a coordinated, multi-organ manner.
Fiona Louise Roberts, Greg Robert Markby
doaj   +1 more source

Zhi-Zi-Chi Decoction Reverses Depressive Behaviors in CUMS Rats by Reducing Oxidative Stress Injury Via Regulating GSH/GSSG Pathway

Frontiers in Pharmacology, 2022
Depression is one of the main diseases that lead to disability and loss of ability to work. As a traditional Chinese medicine, Zhi-zi-chi decoction is utilized to regulate and improve depression.
Yin Zhang, Yin Zhang, Yin Zhang, Yi-Chao Fang, Yi-Chao Fang, Li-Xun Cui, Li-Xun Cui, Yue-Tong Jiang, Yue-Tong Jiang, Yu-Sha Luo, Yu-Sha Luo, Wen Zhang, Wen Zhang, De-Xun Yu, De-Xun Yu, Jun Wen, Jun Wen, Ting-Ting Zhou, Ting-Ting Zhou   +18 more
doaj   +1 more source

Saliva metabolome alterations after acute stress

Scientific Reports, 2022
Major stress has systemic effects on the body that can have adverse consequences for physical and mental health. However, the molecular basis of these damaging effects remains incompletely understood.
Liat Morgan, Rune Isak Dupont Birkler, Shira Shaham-Niv, Yonghui Dong, Tal Wachsman, Lior Carmi, Boris Yakobson, Lihi Adler-Abramovich, Hagit Cohen, Joseph Zohar, Melissa Bateson, Ehud Gazit   +11 more
doaj   +1 more source

Screening of immune cell activators from Astragali Radix using a comprehensive two-dimensional NK-92MI cell membrane chromatography/C18 column/time-of-flight mass spectrometry system

Journal of Pharmaceutical Analysis, 2022
Astragali Radix (AR) is a clinically used herbal medicine with multiple immunomodulatory activities that can strengthen the activity and cytotoxicity of natural killer (NK) cells.
Xinyi Chai, Yanqiu Gu, Lei Lv, Chun Chen, Fei Feng, Yan Cao, Yue Liu, Zhenyu Zhu, Zhanying Hong, Yifeng Chai, Xiaofei Chen   +10 more
doaj   +1 more source

Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells

Frontiers in Pharmacology, 2021
Zhi-zi-chi Decoction (ZZCD), composed of Fructus Gardeniae (Zhizi in Chinese, ZZ in brief) and Semen sojae praeparatum (Dandouchi in Chinese, DDC in brief), has been used as a drug therapy for depression for thousands of years in China.
Yin Zhang, Yin Zhang, Yusha Luo, Yusha Luo, Dongqi Zhang, Bo Pang, Jun Wen, Jun Wen, Tingting Zhou, Tingting Zhou   +9 more
doaj   +1 more source

Transportable hyperpolarized metabolites [PDF]

Nature Communications, 2017
Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao, Bornet, Aurélien, Vuichoud, Basile, Milani, Jonas, Gajan, David, Rossini, Aaron J., Emsley, Lyndon, Bodenhausen, Geoffrey, Jannin, Sami   +8 more
openaire   +5 more sources

Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation. [PDF]

, 2016
ObjectiveProton magnetic resonance spectroscopy (1H MRS) in opiate dependence showed abnormalities in neuronal viability and glutamate concentration in the anterior cingulate cortex (ACC).
Abé, Christoph, Durazzo, Timothy C, Guydish, Joseph, Meyerhoff, Dieter J, Murray, Donna E, Schmidt, Thomas P   +5 more
core   +1 more source

Flux networks in metabolic graphs [PDF]

, 2009
A metabolic model can be represented as bipartite graph comprising linked reaction and metabolite nodes. Here it is shown how a network of conserved fluxes can be assigned to the edges of such a graph by combining the reaction fluxes with a conserved ...
Dantzig G B, J L Jones, Jerrold J H, P B Warren, Palsson B Ø, Press W H, Reed J L, S M Duarte Queiros, Smith E B, Temkin O N   +9 more
core   +1 more source