Results 51 to 60 of about 535,210 (299)

Metabolites in aging and autophagy [PDF]

Microbial Cell, 2014
Sabrina Schroeder, Andreas Zimmermann, Didac Carmona-Gutierrez, Tobias Eisenberg, Christoph Ruckenstuhl, Aleksandra Andryushkova, Tobias Pendl, Alexandra Harger and Frank Madeo* 1 Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria. 2 Division of Endocrinology and Metabolism, Dept.
Tobias Eisenberg, Sabrina Schroeder, Aleksandra Andryushkova, Andreas Zimmermann, Didac Carmona-Gutierrez, Frank Madeo, Tobias Pendl, Christoph Ruckenstuhl, Alexandra Harger   +8 more
openaire   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography

Acta Pharmaceutica Sinica B, 2022
Cell membrane affinity chromatography has been widely applied in membrane protein (MP)-targeted drug screening and interaction analysis. However, in current methods, the MP sources are derived from cell lines or recombinant protein expression, which are ...
Yanqiu Gu, Rong Wang, Panpan Chen, Shengnan Li, Xinyi Chai, Chun Chen, Yue Liu, Yan Cao, Diya Lv, Zhanying Hong, Zhenyu Zhu, Yifeng Chai, Yongfang Yuan, Xiaofei Chen   +13 more
doaj  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma

BMC Cancer, 2019
Background Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression.
Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning, Qingan Jia   +8 more
doaj   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

An Enquiry into Metabolite Domains [PDF]

Biophysical Journal, 2007
It is currently assumed that two or more pools of the same metabolite can coexist in the cytosolic compartment of mammalian cells. These pools are thought to be generated by the differential subcellular location of enzymes and transporters, much in the way calcium microdomains arise by the combined workings of channels, buffers, and pumps. With the aim
Cristián Martínez, L. Felipe Barros
openaire   +3 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Comparative analysis of essential oils found in Rhizomes Curcumae and Radix Curcumae by gas chromatography–mass spectrometry

Journal of Pharmaceutical Analysis, 2011
A comparison of the volatile compounds in Rhizomes Curcumae (Ezhu) and Radix Curcumae (Yujin) was undertaken using gas chromatography–mass spectrometry (GC–MS).
Di-Ya Lü, Yan Cao, Ling Li, Zhen-Yu Zhu, Xin Dong, Hai Zhang, Yi-Feng Chai, Zi-Yang Lou   +7 more
doaj