Results 51 to 60 of about 527,693 (324)

Pharmacokinetics and tissue distribution of Ramulus Mori (Sangzhi) alkaloids in rats and its effects on liver enzyme activity

Frontiers in Pharmacology, 2023
Ramulus Mori (Sangzhi) alkaloids (SZ-A) derived from twigs of mulberry (Morus alba L., genus Morus in the Moraceae family) was approved by the National Medical Products Administration in 2020 for the treatment of type 2 diabetes mellitus.
Zhihua Liu, Yu Feng, Hang Zhao, Hang Zhao, Jinping Hu, Jinping Hu, Yanmin Chen, Yanmin Chen, Yanmin Chen, Dongdong Liu, Dongdong Liu, Hongliang Wang, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Zhufang Shen, Xuejun Xia, Xuejun Xia, Jun Ye, Jun Ye, Yuling Liu, Yuling Liu   +22 more
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Untargeted analysis in post-COVID-19 patients reveals dysregulated lipid pathways two years after recovery

Frontiers in Molecular Biosciences, 2023
Introduction: Similar to what it has been reported with preceding viral epidemics (such as MERS, SARS, or influenza), SARS-CoV-2 infection is also affecting the human immunometabolism with long-term consequences.
Yamilé López-Hernández, Juan José Oropeza-Valdez, David Alejandro García Lopez, Juan Carlos Borrego, Michel Murgu, Jorge Valdez, Jesús Adrián López, Joel Monárrez-Espino   +7 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Effects of pruning on mineral nutrients and untargeted metabolites in fresh leaves of Camellia sinensis cv. Shuixian

Frontiers in Plant Science, 2022
Pruning is an important strategy for increasing tea production. However, the effects of pruning on tea quality are not well understood. In this study, tea leaves were collected from Wuyi Mountain for both ionomic and metabolomic analyses. A total of 1962
Yang Liu, Jing Tian, Bei Liu, Zuopin Zhuo, Chen Shi, Ruineng Xu, Ruineng Xu, Maoxing Xu, Baoshun Liu, Jianghua Ye, Lili Sun, Lili Sun, Hong Liao, Hong Liao   +13 more
doaj   +1 more source

Flow rate of transport network controls uniform metabolite supply to tissue [PDF]

Roy. Soc. Interface, 15, 20180075 (2018), 2017
Life and functioning of higher organisms depends on the continuous supply of metabolites to tissues and organs. What are the requirements on the transport network pervading a tissue to provide a uniform supply of nutrients, minerals, or hormones? To theoretically answer this question, we present an analytical scaling argument and numerical simulations ...
arxiv   +1 more source

Metabolites in aging and autophagy [PDF]

Microbial Cell, 2014
Sabrina Schroeder, Andreas Zimmermann, Didac Carmona-Gutierrez, Tobias Eisenberg, Christoph Ruckenstuhl, Aleksandra Andryushkova, Tobias Pendl, Alexandra Harger and Frank Madeo* 1 Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria. 2 Division of Endocrinology and Metabolism, Dept.
Tobias Eisenberg, Sabrina Schroeder, Aleksandra Andryushkova, Andreas Zimmermann, Didac Carmona-Gutierrez, Frank Madeo, Tobias Pendl, Christoph Ruckenstuhl, Alexandra Harger   +8 more
openaire   +3 more sources

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Using cell membrane chromatography and HPLC-TOF/MS method for in vivo study of active components from roots of Aconitum carmichaeli

Journal of Pharmaceutical Analysis, 2011
An offline two-dimensional system combining a rat cardiac muscle cell membrane chromatography time-of-flight mass spectrometry (CMC-TOF/MS) with a high Performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) was established for ...
Yan Cao, Xiao-Fei Chen, Di-Ya Lü, Xin Dong, Guo-Qing Zhang, Yi-Feng Chai   +5 more
doaj  

Qunatification of Metabolites in MR Spectroscopic Imaging using Machine Learning [PDF]

, 2018
Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite concentration levels.
arxiv   +1 more source