Results 91 to 100 of about 1,007,992 (307)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Microorganisms and nematodes increase levels of secondary metabolites in roots and root exudates of Plantago lanceolata [PDF]

, 2010
Plant secondary metabolites play an important role in constitutive and inducible direct defense of plants against their natural enemies. While induction of defense by aboveground pathogens and herbivores is well-studied, induction by belowground ...
Wurst, S., Biere, A., Van der Putten, W.H., Putten, W.H., van der, Wagenaar, R.   +4 more
core   +1 more source

Air volume not spray concentration determines in vivo efficacy of volatile organic compounds against Plasmopara viticola

Scientific Reports
Volatile organic compounds (VOCs) are produced by plants in response to abiotic and biotic stress stimuli. Two possible modes of action against plant pathogens have been reported for VOCs, such as the induction of plant resistance and direct inhibition ...
Sabine Oberhofer, Sara Avesani, Michele Perazzolli, Peter Robatscher, Urban Spitaler   +4 more
doaj   +1 more source

Identification of the first plant caffeoyl-quinate esterases in Cichorium intybus

Frontiers in Plant Science
Chlorogenic acid (5-CQA) is a caffeic acid ester widely accumulated in higher plants. It plays roles in defense against biotic and abiotic stresses. As its biosynthetic pathway shares common enzymes and intermediates with that of lignin, 5-CQA has long ...
Antoine Mallavergne, David Mathiron, Roland Molinié, Jean-Louis Hilbert, David Gagneul   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae [PDF]

, 2009
Aspergillus westerdijkiae is the main producer of several biologically active polyketide metabolites including isoasperlactone and asperlactone. A 5298 bp polyketide synthase gene ‘‘aomsas” has been cloned in Aspergillus westerdijkiae by using gene ...
Atoui, Ali, Dobson, Alan D. W., Mathieu, Florence, Puel, Olivier, Dao, Huy Phong, Liboz, Thierry, O’Callaghan, John, O'Callaghan, John, Bacha, Nafees, Dobson, Alan D.W., Lebrihi, Ahmed   +10 more
core   +1 more source

Upcycling of By-Products from Autochthonous Red Grapes and Commercial Apples as Ingredients in Baked Goods: A Comprehensive Study from Processing to Consumer Consumption

Antioxidants
Lagrein grape (Vitis vinifera L.) pomace and Scilate apple (Malus domestica Borkh.) skin are polyphenol- and antioxidant-rich by-products with promising applications in the food industry. This study investigated the impact of drying and grinding on their
Gaetano Cardone, Martina Magni, Veronica Marin, Andrea Pichler, Daniele Zatelli, Peter Robatscher, Ombretta Polenghi, Virna Lucia Cerne, Michael Oberhuber, Silvano Ciani   +9 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

The development of a solid-phase fermentation system for the production of pharmaceutically useful secondary metabolites in fungi [PDF]

, 2000
A Phoma species, producing a squalestatin (Si) was grown on agar media derived from wheat, oats, oil seed rape and malt extract over a range of water availability values corresponding to water activity (aa) levels of. 0.998,0.995,0.990,0.980 and 0.960.
Aldred, David
core  

Sulfur Metabolites in the North Pacific Subtropical Gyre and Transition Zone [PDF]

, 2021
Sulfur is an essential nutrient for life and a constituent of many important biomolecules. Phytoplankton in the surface ocean use assimilatory reduction pathways to reduce inorganic sulfur, primarily in the form of sulfate (SO4 2-), into the necessary
Wood, Leland
core