Results 111 to 120 of about 1,007,992 (307)

Use of Ultrasonication Technology for the Increased Production of Plant Secondary Metabolites [PDF]

, 2017
Plant secondary metabolites (PSMs) provide taste, color, odor, and resistance to plants, and they are also used to treat cancer and cardiovascular diseases. Synthesis of PSMs in plants is stimulated in response to different forms of external stress.
Hanhong Bae, Md. Hasan, Tufail Bashir
core   +1 more source

Valproic acid induces antimicrobial compound production in Doratomyces microspores.

Frontiers in Microbiology, 2016
One of the biggest challenges in public health is the rising number of antibiotic resistant pathogens and the lack of novel antibiotics. In recent years there is a rising focus on fungi as sources of antimicrobial compounds due to their ability to ...
Christoph eZutz, Christoph eZutz, Markus eBacher, Alexandra eParich, Bernhard eKluger, Agnieszka eGacek-Matthews, Agnieszka eGacek-Matthews, Rainer eSchuhmacher, Martin eWagner, Kathrin eRychli, Joseph eStrauss, Joseph eStrauss, Joseph eStrauss   +12 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Plant cell and Tissue Culture as a Source of Secondary Metabolites [PDF]

, 2012
Plants are an important source of secondary metabolites that have been used throughout history as drugs, pesticides, pigments, flavors and fragrances. However, one of the main constraints to the use of cultivated plants as a source of these metabolites ...
Castellanos-Hernandez, O.A., Rodriguez-Sahagun, A., Toro-Sanchez, D.C.L., Gutierrez-Lomeli, M.   +3 more
core   +1 more source

Investigating the Medicinal Potential of Lavatera cashmeriana Leaf Extract: Phytochemical Profiling and In Vitro Evaluation of Antimicrobial, Antioxidant, and Anticancer Activities

Advances in Pharmacological and Pharmaceutical Sciences
This study investigated the medicinal potential of Lavatera cashmeriana, a plant traditionally known for its therapeutic properties. The aim was to identify the phytocompounds in L.
Mohmmad Ashaq Sofi, Mohd Abass Sofi, Anima Nanda, Kasi Thiruvengadam, B. K. Nayak   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Metabolites of ethanol as markers of alcohol abuse : glutathione consumption and methionine kinetics in humans [PDF]

, 2004
In the course of the present doctoral studies two projects related to research in alcoholism and relevant for the postgraduate formation of a pharmacist were pursued: one project dealt with the development of analytical tools applicable to the ...
Schmid, Andreas Ulrich
core   +1 more source

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models

Marine Drugs, 2018
A new melatonin analogue 6-hydroxy-N-acetyl-β-oxotryptamine (1) was isolated from the marine-derived fungus Penicillium sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi.
Ekaterina A. Yurchenko, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Phan Thi Hoai Trinh, Elena V. Ivanets, Olga F. Smetanina, Anton N. Yurchenko   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Investigating the diversity of secondary metabolites from filamentous fungi [PDF]

, 2017
Natural products continue to be a fertile source of leads for drug discovery, as a large extent of the world’s biodiversity has been untapped for their chemical diversity and biological activity.
NC DOCKS at The University of North Carolina at Greensboro, Paguigan, Noemi D.   +1 more
core