Results 121 to 130 of about 1,007,992 (307)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Impact of cytochrome P450 2D6 function on the chiral blood plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its phase I and II metabolites in humans [PDF]

, 2016
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by ...
Tingelhoff, Eva H., Eva H. Tingelhoff, Schmidhauser, Corina, Steuer, Andrea E, Yasmin Schmid (3181563), Eva H. Tingelhoff (3181572), Schmid, Yasmin, Tingelhoff, Eva H, Andrea E. Steuer (1712023), Anna Rickli (3181569), Yasmin Schmid, Anna Rickli, Thomas Kraemer (271037), Liechti, Matthias E., Matthias E Liechti, Liechti, Matthias E, Corina Schmidhauser, Andrea E. Steuer, Rickli, Anna, Matthias E. Liechti (166584), Eva H Tingelhoff, Thomas Kraemer, Andrea E Steuer, Corina Schmidhauser (3181566), Steuer, Andrea E., Matthias E. Liechti, Kraemer, Thomas   +26 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Chemical composition of anti-microbially active fractions derived from extract of filamentous fungus Keratinophyton Lemmensii including three novel bioactive compounds

Scientific Reports
Screening for new bioactive microbial metabolites, we found a novel okaramine derivative, for which we propose the trivial name lemmokaramine, as well as two already known okaramine congeners – okaramine H and okaramine J - responsible for antimicrobial ...
Roman Labuda, Markus Bacher, Thomas Rosenau, Hannes Gratzl, Maria Doppler, Sonja Hager, Doris Marko, Christoph Wiesner, Monika Očková, Nicole Ollinger, Martin Wagner, Christoph Schüller, Joseph Strauss   +12 more
doaj   +1 more source

Saksenaea dorisiae sp. nov., a New Opportunistic Pathogenic Fungus from Europe

International Journal of Microbiology, 2019
A new species, Saksenaea dorisiae (Mucoromycotina, Mucorales), isolated from a water sample originating from a private well in Manastirica, Petrovac, in the Republic of Serbia (Europe), is described and illustrated.
Roman Labuda, Andreas Bernreiter, Doris Hochenauer, Christoph Schüller, Alena Kubátová, Joseph Strauss, Martin Wagner   +6 more
doaj   +1 more source

Diversity of Microbial Communities and Quantitative Chemodiversity in Layers of Marine Sediment Cores from a Causeway (Kaichu-Doro) in Okinawa Island, Japan

Frontiers in Microbiology, 2017
Microbial community diversity and chemodiversity were investigated in marine sediments adjacent to the Okinawan “Kaichu-Doro” Causeway, which was constructed 46 years ago to connect a group of four islands (Henza-jima, Miyagi-jima, Ikei-jima, Hamahiga ...
Taha Soliman, Taha Soliman, Taha Soliman, James D. Reimer, James D. Reimer, Sung-Yin Yang, Sung-Yin Yang, Alejandro Villar-Briones, Michael C. Roy, Holger Jenke-Kodama   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco [PDF]

, 2009
This study reports the chemical investigation and cytotoxic activity of the secondary metabolites produced by the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. This plant was collected from the Beni-Mellal Mountain
Mueller, W.E.G., Hakikj, Adbelhak, Mueller, Werner E. G., Proksch, Peter, Ebel, R., Debbab, Abdessamad, Edrada-Ebel, RuAngelie, Ebel, Rainer, Aly, Amal Hassan, Edrada-Ebel, Ru Angelie, Mosaddak, Mahjouba, Hakiki, Abdelhak, Aly, Amal H., Debbab, Adbessamad   +13 more
core   +1 more source