Results 151 to 160 of about 1,454,594 (288)

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Ion‑Mediated Structural Engineering of Hydrogel Interfaces for Tunable Mechanical and Analyte Diffusion Properties in Electrochemical Biosensors

Advanced Materials, EarlyView.
An ion‐mediated structural engineering strategy enables versatile modulation of PVA–Alginate hydrogel microstructure. We systematically examine how different ion combinations affect hydrogel mechanical properties and analyte diffusivity. Applying this novel strategy to hydrogel as the outer membrane in an electrochemical glucose biosensor allows ...
Dongwook Lee, Soo A Kim, Beom‐Jun Shim, Yurim Lee, Tae Young Kim, Sunghyun Park, Yeontaek Lee, Hyeong Gyu Choi, Kayoung Son, Su Bin Han, Keun‐Young Yook, Seo Jung Kim, Won‐Yong Lee, Jungmok Seo, Jayoung Kim   +14 more
wiley   +1 more source

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Plasma Metabolite Associations for Risk and Laboratory Measures of Type 2 Diabetes in a Large-Scale Finnish Prospective Cohort. [PDF]

Diabetes Care
Liu L, Peng R, Chu X, Xia Z, Fu Q, Fernandes Silva L, Stringham HM, Hu X, Liang Y, Ji X, Li J, Yang T, Morrison J, Wen X, Fauman E, Burant CF, Scott LJ, Boehnke M, Laakso M, Yin X.   +19 more
europepmc   +1 more source

Oxygen‐Inhibition Driven Compartmentalization of Dextran Microgels: Toward Fusible Colloidal Biomaterial Inks for 3D Printing

Advanced Materials, EarlyView.
Harnessing oxygen inhibition as a materials design principle enables the universal fabrication of core–shell microgels with tunable radial crosslinking gradients. This conceptually simple yet highly versatile strategy generates fusible colloidal bioinks that combine structural hierarchy with adaptive porosity.
Selin Bulut, Thomas Bissing, Tudor Lile, Hannah Küttner, Daniel Günther, Cédric Bergerbit, Dan Eugen Demco, Laura De Laporte, Andrij Pich   +8 more
wiley   +1 more source

Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin. [PDF]

J Clin Invest
Leone VA, Frazier K, Kaur M, Chrisler EA, Sidebottom AM, Tai E, Tran V, Li S, Chang EB, Jones DP, Van Cauter E, Hanlon EC.   +11 more
europepmc   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source

Gold Nanorods in Cardiac Millitissues: Assessing Mechanical and Contractile Dynamics in a Living Engineering Myocardium Model

Advanced Materials Technologies, EarlyView.
This study presents a novel platform for assessing the active mechanical behavior of living cardiac microbundles through localized nanoindentation, integrated with temperature regulation and dual‐camera imaging systems. The developed system enables quantitative evaluation of dynamic micromechanics in engineered cardiac tissues in vitro, offering ...
Lihua Lou, Lia Paolino, Alberto Sesena Rubfiaro, Jin He, Arvind Agarwal   +4 more
wiley   +1 more source

Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study. [PDF]

PLoS Med
Zheng Y, Yang JJ, Gupta DK, Herrington DM, Yu B, Nguyen NQH, Pinto R, Tzoulaki I, Cai H, Cai Q, Lipworth L, Shu XO, Zheng W, Yu D.   +13 more
europepmc   +1 more source

Fabrication Technologies for Soft, Multimaterial Optical Fibers for In Vivo Diagnostics and Phototherapy, With a Focus on Extrusion Printing

Advanced Materials Technologies, EarlyView.
Soft multimaterial optical fibers integrate multiple functionalities—such as waveguiding, side emission, sensing, drug delivery or actuation—into a single filament for wearable, implantable, and tissue‐integrated devices for diagnostics and phototherapy.
Zahra Kafrashian, Jun Feng, Aránzazu del Campo   +2 more
wiley   +1 more source