Results 231 to 240 of about 1,469,719 (306)

Removal of C-ring from the CD-ring skeleton of 1 alpha,25-dihydroxyvitamin D-3 does not alter its target tissue metabolism significantly [PDF]

, 2007
BOUILLON, R, De Clercq, Pierre, GENNARO, L, LING, S, PALINORE, GTR, REDDY, GS, ROBINSON, M, Vandewalle, Maurits, VERSTUYF, A, VOUROS, P, WANG, G, YONG, W   +11 more
core   +1 more source

Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin. [PDF]

J Clin Invest
Leone VA, Frazier K, Kaur M, Chrisler EA, Sidebottom AM, Tai E, Tran V, Li S, Chang EB, Jones DP, Van Cauter E, Hanlon EC.   +11 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Metabolite-based genome-wide association analysis reveals genetic loci and candidate genes affecting breast muscle metabolites in Sansui ducks. [PDF]

Poult Sci
Feng Y, Xu M, Yu X, Yang Z, Qi J, Xi Y, Guo S, Han X, Li M, Lu Y, Dai G, Tian C, Zhao Y, Huang A, Li L, Liu H.   +15 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Identification of plasma biomarkers in lipid metabolism for accurate prediction of Alzheimer's disease. [PDF]

Transl Psychiatry
Luo X, Jia L, Cao J, Guo Q, ZIB Consortium, Chen J, Zhao XM.   +6 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Ikawa K, Morikawa N, Sakata M, Horikawa N.   +3 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Development of a Quantitative Serial LC-MS/MS Method for Gut Microbiota Metabolomics. [PDF]

ACS Omega
Yoshida T, Shintani T, Sasaki D, Vavricka CJ, Matsuki Y, Kondo A, Hasunuma T.   +6 more
europepmc   +1 more source