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Metabolite Damage and Metabolite Damage Control in Plants
Annual Review of Plant Biology, 2016It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites.
Andrew D, Hanson +3 more
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Mexiletine Metabolites: A Review
Current Medicinal Chemistry, 2015Mexiletine belongs to class IB antiarrhythmic drugs and it is still considered a drug of choice for treating myotonias. However some patients do not respond to mexiletine or have significant side effects limiting its use; thus, alternatives to this drug should be envisaged.
Catalano A., Carocci A., Sinicropi M. S.
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Metabolites, enzymes, and metabolite analogues
1973The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 2. The present chapter deals in greater detail with one cause of high specificity, namely a close resemblance between (a) the normal substrate (or coenzyme) of an ...
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The Biosynthesis of Shikimate Metabolites
ChemInform, 1999AbstractFor Abstract see ChemInform Abstract in Full Text.
Andrew R. Knaggs +2 more
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Advances in Metabolite Identification
Bioanalysis, 2011One of the central challenges to metabolomics is metabolite identification. Regardless of whether one uses so-called 'targeted' or 'untargeted' metabolomics, eventually all paths lead to the requirement of identifying (and quantifying) certain key metabolites.
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Gut Microbial Metabolites as Multi-Kingdom Intermediates
Nature Reviews Microbiology, 2021Fredrik Bäckhed +2 more
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