Results 241 to 250 of about 1,469,719 (306)

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

Advanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu, Meijia Zhang, Maoping Cai, Miao Wang, Ziao Huang, Zesheng Lin, Yixin Liu, Wang Qian, Guopeng Chen, Yuxing Liang, Dongyi Wei, Jing xie, Picheng Yan, Yuanyuan Qu, Yongchang Wei   +14 more
wiley   +1 more source

Decoding the Metabolic Signatures of Neurodegeneration Diseases: Advances in Mass Spectrometry-Based Metabolomics. [PDF]

Metabolites
Hakim MA, Li L.
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Perks of being a wallflower: a high-quality wallflower reference genome reveals its chromosome evolution and flower color variation. [PDF]

Plant Physiol
Thomas WJW.
europepmc   +1 more source

Analysis of Metabolic Differences and Core Regulatory Pathways in Lactic Acid Bacteria-Fermented Broths of Different <i>Ziziphus jujuba</i> Mill. Varieties Based on LC-MS Untargeted Metabolomics. [PDF]

Foods
Zhang J, Ye Z.
europepmc   +1 more source

Loss of Kv8.2 in the Mouse Retina Is Associated With Altered One-Carbon Metabolism. [PDF]

J Neurochem
Kruth K, Baker SA.
europepmc   +1 more source

Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging. [PDF]

NPJ Aging
Rafiq T, Ma J, Joshi D, Mayhew A, Griffith L, van den Heuvel E, Raina P.   +6 more
europepmc   +1 more source

Serum untargeted metabolomics reveals key pathways in feline mammary carcinoma for comparative oncology. [PDF]

Metabolomics
de Sá HC, Rodrigues GM, de Carvalho VMP, Silva LP, Kato MJ, Estrela-Lima A, Canuto GAB.   +6 more
europepmc   +1 more source