Results 241 to 250 of about 1,006,561 (307)

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Enhancing secondary metabolite accumulation in medicinal plants to improve immunomodulatory activity. [PDF]

Front Pharmacol
Mkhize P, Morafo V, Mbita Z.
europepmc   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

The hypoglycemic metabolites and potential mechanisms of <i>Lilium lancifolium</i> (<i>Juandan</i> lily). [PDF]

Front Pharmacol
Wu Q, Xiao K, Zhao D, Tang R, Liu W, Li F, Wang H, Chen F.   +7 more
europepmc   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

MetaboVariation 2.0: Multivariate analysis for identifying metabolite variation at the individual level. [PDF]

PLoS One
Gupta S, Gormley IC, Brennan L.
europepmc   +1 more source

Metabolomic profiling reveals dynamic lipid reprogramming during adipogenesis in 3T3-L1 cells. [PDF]

Front Mol Biosci
Shi N, Huang Z, Liu J, Sun W, Li J.
europepmc   +1 more source

A comparative study on meat quality traits and metabolomic profiles of different duck breeds following water boiling. [PDF]

Poult Sci
Fan Z, Wu X, Liu H, Chen Z, Yang Z, Liu H, Li L.   +6 more
europepmc   +1 more source

Serum Untargeted Metabolomics Profiling of Esophageal Squamous Cell Carcinoma in High-Incidence Areas of China. [PDF]

Int J Gen Med
Li Y, Zhou L, Huang R, Wu Z, Guan J, Qiao X, Kong Y, Gan Y, Zhang Y, Li J.   +9 more
europepmc   +1 more source