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Drug Metabolism and Disposition, 2013
Characterization of the circulating metabolites for a new chemical entity in humans is essential for safety assessment, an understanding of their contributions to pharmacologic activities, and their potential involvement in drug-drug interactions. This review examines the abundance of metabolites relative to the total parent drug [metabolite-to-parent (
Cho-Ming, Loi +2 more
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Characterization of the circulating metabolites for a new chemical entity in humans is essential for safety assessment, an understanding of their contributions to pharmacologic activities, and their potential involvement in drug-drug interactions. This review examines the abundance of metabolites relative to the total parent drug [metabolite-to-parent (
Cho-Ming, Loi +2 more
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Metabolites, enzymes, and metabolite analogues
1973The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 2. The present chapter deals in greater detail with one cause of high specificity, namely a close resemblance between (a) the normal substrate (or coenzyme) of an ...
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Journal of Pharmaceutical Sciences, 1974
Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E, Zarembo +3 more
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Microbial transformation of the alkaloid mitragynine by the fungus Helminthosporum sp. has elaborated two major metabolites. The compounds were isolated from the biological milieu and their structures were elucidated as mitragynine pseudoindoxyl and hydroxy mitragynine pseudoindoxyl.
J E, Zarembo +3 more
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2015
Secondary metabolites are those compounds which are produced by certain microorganisms in a phase of subsequent to growth, may have some survival function, have unusual chemical structures, and are formed as mixtures of closely related members of a chemical family.
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Secondary metabolites are those compounds which are produced by certain microorganisms in a phase of subsequent to growth, may have some survival function, have unusual chemical structures, and are formed as mixtures of closely related members of a chemical family.
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Fibrinolytic Bacterial Metabolite
Nature, 1962IN the course of work on auto-antibodies in patients suffering from multiple myeloma marked fibrinolytic activity was discovered in one of the sera. Further investigation revealed that it was contaminated with two kinds of bacteria, one a member of the genus Pseudomonas, the other a strain of Streptococcus faecalis. The role of Pseudomonas was shown to
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Metabolite Profiling of Actinobacterial Metabolites
2020Ramasamy Balagurunathan +4 more
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