Results 51 to 60 of about 1,469,719 (306)

Implication of metabolism in the polarization of tumor-associated-macrophages: the mass spectrometry-based point of view

Frontiers in Immunology, 2023
Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated ...
Giulia De Simone, Giulia De Simone, Cristiana Soldani, Aurelia Morabito, Aurelia Morabito, Barbara Franceschini, Fabrizio Ferlan, Guido Costa, Guido Costa, Guido Costa, Roberta Pastorelli, Matteo Donadon, Matteo Donadon, Matteo Donadon, Matteo Donadon, Laura Brunelli   +15 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval [PDF]

, 2013
Death is likely to result in very extensive biochemical changes in all body tissues due to lack of circulating oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic production of metabolites.
Donaldson, Andrea
core   +1 more source

Analysis of Human Faecal Host Proteins: Responsiveness to 10-Week Dietary Intervention Modifying Dietary Protein Intake in Elderly Males

Frontiers in Nutrition, 2021
Faecal proteomics targeting biomarkers of immunity and inflammation have demonstrated clinical application for the identification of changes in gastrointestinal function.
Jessica L. Gathercole, Anita J. Grosvenor, Erin Lee, Ancy Thomas, Cameron J. Mitchell, Cameron J. Mitchell, Nina Zeng, Randall F. D'Souza, Randall F. D'Souza, Farha Ramzan, Pankaja Sharma, Scott O. Knowles, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Nicole C. Roy, Anders Sjödin, Karl-Heinz Wagner, Amber M. Milan, Amber M. Milan, Sarah M. Mitchell, David Cameron-Smith, David Cameron-Smith   +23 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mapping an atlas of tissue-specific drosophila melanogaster metabolomes by high resolution mass spectrometry [PDF]

, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
A Kamleh, A Malmendal, A Malmendal, AA Jackson, C Jeulin, David G. Watson, DG Watson, DJ Creek, Dominika Korzekwa, DT Sullivan, G Di Paolo, G Fraenkel, GJ Blomquist, GX Quan, H Colinet, J Andrews, J Overgaard, Jacob Guy Bundy, JD Feala, JE Treherne, JL Hubby, JS Park, Julian A. T. Dow, KS Pedersen, L Coquin, L Pan, L Zheng, M Carvalho, M Parisi, M Rera, MA Kamleh, MA Kamleh, MF Wolfner, MM Green, Mohammed Al Bratty, MS Elias, N Vereshchagina, NE Braverman, P Niewiadomska, PA Robitaille, PS Shekhawat, R Tearle, S Buch, S Reisse, V Kostal, Venkateswara R. Chintapalli, VR Chintapalli, VR Chintapalli   +47 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Comparison of Total Phenolic Content, Scavenging Activity and HPLC-ESI-MS/MS Profiles of Both Young and Mature Leaves and Stems of

Natural Product Communications, 2013
The total phenolic content and radical scavenging activity of Andrographis paniculata has been investigated to estimate the amount of phenolic compounds and diterpene lactones, respectively in the plant extracts.
Lee Suan Chua, Ken Choy Yap, Indu Bala Jaganath   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Acaricidal properties of extracts of some medicinal and culinary plants against Tetranychus urticae Koch.

Plant Protection Science, 2016
The acaricidal activity of aqueous extracts obtained from 28 plant species was tested against Tetranychus urticae. The extract efficacy on the incidence of individual development stages of T.
Roman Pavela
doaj   +1 more source