Results 81 to 90 of about 2,167,847 (388)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The role of the gut microbiome and its metabolites in metabolic diseases

Protein & Cell, 2020
It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of
Jiayu Wu, Kai Wang, Xuemei Wang, Yanli Pang, Changtao Jiang   +4 more
semanticscholar   +1 more source

Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers

Microbiome, 2022
Background Gut microbiota contributes to colorectal cancer (CRC) pathogenesis through microbes and their metabolites. The importance of microbiota-associated metabolites in colorectal carcinogenesis highlights the need to investigate the gut metabolome ...
O. Coker, Changan Liu, W. Wu, S. Wong, Wei Jia, J. Sung, Jun Yu   +6 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effectiveness of environmentally safe food additives and food supplements in an in vitro growth inhibition of significant Fusarium, Aspergillus and Penicillium species

Plant Protection Science, 2018
We tested 38 legislatively recognised substances such as food additives and supplements for antifungal efficacy, with the aim of providing an alternative to synthetic conventional fungicides.
Martin Žabka, Roman Pavela
doaj   +1 more source

Volatile linalool activates grapevine resistance against downy mildew with changes in the leaf metabolome

Current Plant Biology, 2023
Volatile organic compounds (VOCs) are produced by plants in response to biotic and abiotic stimuli. In grapevine, volatile terpenoids are triggered by downy mildew infection (caused by Plasmopara viticola), suggesting their involvement in plant defense ...
Sara Avesani, Valentina Lazazzara, Peter Robatscher, Michael Oberhuber, Michele Perazzolli   +4 more
doaj   +1 more source

Endocidal Regulation of Secondary Metabolites in the Producing Organisms [PDF]

, 2016
Secondary metabolites are defined as organic compounds that are not directly involved in the normal growth, development, and reproduction of an organism.
Bullard, Steven H, Li, Shiyou, Su, Zushang, Wang, Ping, Yuan, Wei   +4 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

History, presence and perspective of using plant extracts as commercial botanical insecticides and farm products for protection against insects - a review

Plant Protection Science, 2016
Botanical insecticides keep attracting more attention from environmental and small farmers worldwide as they are considered as a suitable alternative to synthetic insecticides.
Roman PAVELA
doaj   +1 more source

Signatures of currency vertices

, 2008
Many real-world networks have broad degree distributions. For some systems, this means that the functional significance of the vertices is also broadly distributed, in other cases the vertices are equally significant, but in different ways.
Albert R., Arita M., Buckley F., Caldarelli G., Ebel H., Gleiser P., Guimerà R., Guimerà R., Guimerà R., Holme P., Holme P., Holme P., Huss M., Lusseau D., Ma H.-W., Maslov S., Newman M. E. J., Newman M. E. J., Newman M. E. J., Newman M. E. J., Rosvall M., Solé R. V., Wagner A., Wasserman S., White J. G., Zhao J., Zhao J.   +26 more
core   +1 more source