Results 141 to 150 of about 1,692 (289)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Indian Journal of Animal SciencesThis study investigated the effects of rice distillers grains with solubles (rDDGS) on growth performance, production efficiency, carcass characteristics, nutrient metabolizability and serum biochemistry of dual purpose chicken (Kuroiler).
TAPAN KUMAR DAS +7 more
doaj +1 more source
EFFECT OF EXOGENOUS ENZYMES ON APPARENT METABOLIZABLE ENERGY VALUE OF BARLEY IN SWINE AND BROILER CHICKENS [PDF]
, 2018 The objective of this thesis was to evaluate the effect of exogenous enzyme supplementation, phytase and xylanase-glucanase, on AME value of barley in poultry and swine. In the first study, 280 broilers were assigned 1 of 8 treatments.
Bryson, Brian L.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cattle herd dynamics: An integer and stochastic model for evaluating production alternatives [PDF]
, 2011 Presents a cattle herd simulation model which is time dynamic, stochastic, non-optimizing & integer and permits the evaluation of herd performance under alternative production regimes; discusses the analytical background to the biological relationships ...
Anderson, F.M., Konandreas, P.A.
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Can the fine wheat bran be a betaine source in poultry diets? [PDF]
, 2019 The effect of fine wheat bran (FWB) as a methyl donor source on performance, metabolism, body composition and blood traits of growing broilers was studied.
Bockor, Luciane +5 more
core
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
A Bioassay for True Metabolizable Energy in Feedingstuffs
Poultry Science, 1976 In 12 experiments with S.C.W.L. roosters it was shown that for each of 12 feedingstuffs there was a linear relationship between feed input and the amount of energy voided as excreta. In the 24 h. period, following 21 hr. of starvation, roosters receiving no feed excreted 4.07 kcal./kg. of body weight.
openaire +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source