Results 171 to 180 of about 114,008 (316)

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

iMetaOmics, EarlyView.
This graphical abstract outlines a multi‐omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high‐altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). By integrating dietary DNA metabarcoding, 16S rRNA gene sequencing, shotgun
Dilala Tuoliu, Lijiao Zhang, Muyang Wang, Wenxuan Xu, Kathreen Ruckstuhl, António Alves da Silva, Joana Alves, Hongchen Jiang, Weikang Yang   +8 more
wiley   +1 more source

Multi‐omics reveals gastrointestinal metabolic disorder‐induced diarrhea in postpartum dairy cows

iMetaOmics, EarlyView.
Nutritional diarrhea is a pervasive, costly challenge in dairy production. Using integrated metagenomic and metabolomic profiling, we identified coordinated microbial and metabolic alterations across the rumen, hindgut, and serum. In the rumen, enrichment of Prevotella sp.
Weixuan Tang, Yangyi Hao, Jiawei Zhang, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li   +7 more
wiley   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Metabolomics in the wild: A scoping review of non-invasive methods for understanding vertebrate wildlife health and success. [PDF]

PLoS One
Mogey R, Goodacre R, Curtis F, Maden M, Edwards KL.   +4 more
europepmc   +1 more source

Lactobacillus johnsonii attenuates ovarian aging by remodeling the gut–ovary axis

iMetaOmics, EarlyView.
Aging is accompanied by a reduced abundance of L. johnsonii and ovarian decline. Supplementation with L. johnsonii elevates microbial IPA production via the LdhA enzyme and commensal bacteria. IPA activates the AhR/YAP signaling axis, promoting YAP nuclear translocation and inducing the expression of downstream target genes CYR61 and CTGF. This cascade
Jiamin He, Qiwen Wang, Luyi Chen, Yadong Qi, Dingjiacheng Jia, Jilei Xu, Qingyi Wang, Yao Jiang, Jian Zhou, Yong Sun, Ruochen Yan, Lan Wang, Tongyao Hou, Zheng Kuang, Min Jin, Liangjing Wang, Shujie Chen   +16 more
wiley   +1 more source

Integrating complementary datasets for constructing microbiome-metabolome-disease pathways. [PDF]

Bioinformatics
Fang L, Ye C, Wang Y.
europepmc   +1 more source

Tools for metabolomics [PDF]

Nature Methods, 2020
openaire   +2 more sources

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma. [PDF]

Metabolomics
Turi KN, Wu X, Li Y, Rosas-Salazar C, Gebretsadik T, Shilts MH, Das SR, Gern J, Xu Y, Hartert TV.   +9 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source