Results 181 to 190 of about 141,099 (288)

The Emerging Short Chain Fatty Acid Enriched Metabotype in Irritable Bowel Syndrome and Its Potential Clinical Relevance

Alimentary Pharmacology &Therapeutics, EarlyView.
In a cohort of IBS‐D patients recruited to the TRITON study, faecal metabolomic profiling reveals a SCFA‐enriched metabotype associated with increased pain and urgency, altered stool characteristics and accelerated intestinal transit. ABSTRACT Background Metabolomic analysis in irritable bowel syndrome (IBS) has identified metabotypes enriched in ...
T. E. Conley, A. Duncan, A. Modasia, A. C. Ford, D. M. Pritchard, F. Hildebrand, F. J. Warren, R. Spiller, C. S. Probert   +8 more
wiley   +1 more source

Untargeted Metabolomics Analysis of Human Milk from Breastfeeding Bangladeshi Women Reveals Amino Acid Metabolic Pathways Associated with Maternal Nutritional Status and Infant Growth. [PDF]

J Nutr
Monthe-Dreze C, Bhushan B, Andrews C, Cherkerzian S, Perng W, Ahmed S, Baqui AH, Chowdhury N, Khanam R, Rahman S, Sheridan PA, Michelotti G, Martin CR, Lee AC, Sen S.   +14 more
europepmc   +1 more source

Impact of preservation conditions on the fecal metabolome and lipidome [PDF]

, 2019
De Spiegeleer, Margot, Huysman, Steve, Van Meulebroek, Lieven, Vanhaecke, Lynn   +3 more
core   +1 more source

Changes in the microbiome and metabolome in captive red kangaroos (Osphranter rufus) affected by macropod progressive periodontal disease

Australian Veterinary Journal, EarlyView.
Macropod progressive periodontal disease (MPPD) is a severe oral condition frequently observed in captive macropods, particularly red kangaroos (Osphranter rufus), yet its underlying biological features remain poorly understood. In this exploratory descriptive study, we investigated oral and fecal microbiomes and metabolomic profiles in captive red ...
Y Yoshimoto, N Nagata, R Inoue, Y Yamamoto, K Nagaoka   +4 more
wiley   +1 more source

Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells

Brain Pathology, EarlyView.
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son, Suji Kim, Min‐Tae Jeon, Moonseok Choi, Kyu‐Sung Kim, Suji Lee, Seung‐Yeol Nah, Do‐Geun Kim   +7 more
wiley   +1 more source

Dogs and humans share biomarkers of mortality. [PDF]

J Gerontol A Biol Sci Med Sci
Harrison BR, Akey JM, Snyder-Mackler N, Raftery D, Creevy KE, Promislow DEL, DAP Consortium.   +6 more
europepmc   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Integrating intestinal microbiome and urinary metabolome data to predict secondary infection in critically ill patients. [PDF]

Crit Care
Linz C, Tsenova K, Dettmer K, Ellmann L, Oefner PJ, Gronwald W, Farowski F, Rüb AM, Freedberg DE, Koehler P, Borrega JG, Naendrup JH, Vehreschild MJGT, Böll B.   +13 more
europepmc   +1 more source

Gas Chromatography-Mass Spectrometry (GC-MS) in the Plant Metabolomics Toolbox: GC-MS in Multi-Platform Metabolomics and Integrated Multi-Omics Research. [PDF]

Int J Mol Sci
Frolova N, Bilova T, Silinskaia S, Orlova A, Gurina A, Frolov A.   +5 more
europepmc   +1 more source

The Gut Microbiome as a Therapeutic Target in Alopecia Areata: Not Yet Part of the Patient Treatment Plan

International Journal of Dermatology, EarlyView.
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen, Deema Abdel Hafeez, Nikhil Pai, Laurence Mainville, Shireen Dumont, Narachai Julanon, Romy Shenderey, Grace Xiong, Shahnawaz Towheed, Jeffrey Donovan   +9 more
wiley   +1 more source