Results 201 to 210 of about 114,008 (316)

KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis

Med Research, EarlyView.
The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao, Guohui Yu, Shikui Wu, Zhiyang Zhang, Keke Wang, Yingxin Xiong, Chao Sun, Haobo Cui, Yuxing Wang, Ziheng Wang, Huiru Zhang, Huiqin Xue, Shibing Guo   +12 more
wiley   +1 more source

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source

Phenotype-Aware Biomarker Discovery in Childhood Asthma: Microbiome-Metabolome Signatures and Translational Readiness. [PDF]

Int J Gen Med
Dong J, Lv J, Sun G, Xiao Z.
europepmc   +1 more source

Mapping Tumor Recurrence and Metastasis With Pan‐Cancer Multi‐Omics

Med Research, EarlyView.
Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context‐dependent modifiers. Clonal evolution, including genomic instability, subclonal selection, and treatment pressure, interacts with reversible cell‐state plasticity involving partial EMT, stemness, and dormancy, whereas immune escape, stromal remodeling,
Wenjun Meng, Ruicen Li, Xiaoli Mu, Xiaolong Tang, Yuxi Luo, Yingying Lei, Jinghong Xian, Guiyi Ji, Yihao Liu, Chenyu Huo, Sihan Li, Yalun Li, Jiadi Gan, Weimin Li   +13 more
wiley   +1 more source

Breastfeeding type is associated with urinary metabolic changes in early life: influence of sex and early weight gain in healthy term infants. [PDF]

Mol Cell Pediatr
Bibiloni P, Martin JC, Cobo P, De Lucas M, Jiménez-Cabanillas MV, Tardivel C, Picó C, Serra F, Sánchez J.   +8 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Gut microbiome and gut-derived metabolites to identify the transition from metabolically healthy to unhealthy obesity: a mini review. [PDF]

Front Nutr
Manrique EI, Sciglitano L, Ortega-Santos CP.   +2 more
europepmc   +1 more source

Planting for healthy air: Urban biodiversity enhances natural chemical environments

PLANTS, PEOPLE, PLANET, EarlyView.
Cities urgently need nature to improve public health, support biodiversity, and increase resilience to climate change. Yet not all green spaces offer the same benefits. In this study, we show that more diverse urban plantings create richer “chemical environments”; subtle, naturally scented atmospheres formed by plant emissions that can influence how ...
Aurora Ruggeri, Fethi Ben Fraj, Gaetan Glauser, Gregory Röder, Ola Söderström, Sergio Rasmann   +5 more
wiley   +1 more source

A Metabolome Atlas of Grape Biodiversity. [PDF]

J Agric Food Chem
Arapitsas P, Franceschi P, Garcia-Aloy M, Vrhovsek U, Narduzzi L, Masuero D, Stefanini M, Bettinelli P, Grando MS, Emanuelli F, Wehrens R, Theodoridis G, Mattivi F.   +12 more
europepmc   +1 more source

Endophytic fungi from two isolated Bethencourtia palmensis populations: metabolomic and bioactivity fingerprinting

Pest Management Science, EarlyView.
We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero, Juan Imperial, Carmen Elisa Díaz, María Fe Andrés, Azucena González‐Coloma   +4 more
wiley   +1 more source