Results 241 to 250 of about 98,733 (348)

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Selection for Early Reproduction Leads to Accelerated Aging and Extensive Metabolic Remodeling in Drosophila melanogaster. [PDF]

Genome Biol Evol
Hubert DL, Arnold KR, Greenspan ZS, Pupo A, Robinson RD, Chavarin VV, Barter TT, Djukovic D, Raftery D, Vue Z, Hinton A, McReynolds MR, Harrison BR, Phillips MA.   +13 more
europepmc   +1 more source

Metabolome in schizophrenia and other psychotic disorders: a general population-based study [PDF]

, 2011
Matej Orešič, Jing Tang, Tuulikki Seppänen‐Laakso, Ismo Mattila, Suoma Saarni, Samuli I. Saarni, Jouko Lönnqvist, Marko Sysi‐Aho, Tuulia Hyötyläinen, Jonna Perälä, Jaana Suvisaari   +10 more
openalex   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

Temporal Changes in Blood Metabolome: Understanding Biochemical Changes in Hemodialysis Patients. [PDF]

Kidney Int Rep
Aleidi SM, Rahman AA.
europepmc   +1 more source

Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis [PDF]

, 2011
Cedric Shackleton
openalex   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

The inferred modulation of correlated vaginal microbiota and metabolome by cervical differentially expressed genes across distinct CIN grades. [PDF]

BMC Microbiol
Dai W, Liu Y, Jiang X, Xu R, Guo C, Hou J, Wu D, Li C, Du H, Wu R.   +9 more
europepmc   +1 more source

Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates

, 2009
Helena Gleissman, Yang Rong, Kimberly Martinod, Magnus Lindskog, Charles N. Serhan, John Inge Johnsen, Per Kogner   +6 more
openalex   +2 more sources

Mass Spectra-Based Framework for Automated Structural Elucidation of Metabolome Data to Explore Phytochemical Diversity [PDF]

, 2011
Fumio Matsuda, Ryo Nakabayashi, Yuji Sawada, Makoto Suzuki, Masami Yokota Hirai, Shigehiko Kanaya, Kazuki Saito   +6 more
openalex   +1 more source