Results 221 to 230 of about 159,394 (302)

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Integrative Analysis of the Metabolome and Transcriptome Reveals the Mechanism Underlying Differences in Skin Development Between the New Zealand Rabbit and the Rex Rabbit. [PDF]

Animals (Basel)
Zhao B, Cai J, Bai Z, Chen T, Fan A, Cao X, Chen Y, Wu X.   +7 more
europepmc   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Integrated Metabolomic and Transcriptomic Analyses of Longissimus Thoracis Muscle Provide Insights into Metabolic Differences Between Yanbian and Yanhuang Cattle. [PDF]

Biology (Basel)
Lyu Y, Zhu Z, Zhao B, Ren Z, Zhou M, Yu J, Ding H, Liu H, Fang Y, Zhao J, Lyu W.   +10 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Metabolomic Profiling in Children with Sleep Disorders: An Exploratory Pilot Study. [PDF]

J Clin Med
Pintus R, Evangelisti M, Piras C, Arpinelli M, Vassilios F, Noto A, Di Nardo G, Villa MP.   +7 more
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Exploratory NMR-based metabolomics reveals transient lipoprotein changes during prolonged computer gaming. [PDF]

Metabolomics
Krarup KB, Krarup HB, Pedersen IS, Mørk M, Kristensen SR, Handberg A, Wimmer R, Nguyen HTT.   +7 more
europepmc   +1 more source

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Salivary Metabolomics: A Pilot Study for Screening Biomarkers in Mild-to-moderate Periodontitis. [PDF]

In Vivo
Edamatsu K, Ishikawa S, Sugimoto M, Okuyama N, Yusa K, Kitabatake K, Hemmi T, Iino M.   +7 more
europepmc   +1 more source