Results 101 to 110 of about 297,367 (349)

Patritumab deruxtecan induces immunogenic cell death

OncoImmunology
Antibody-drug conjugates (ADCs) enable targeted delivery of cytotoxic payload to cancer cells. Here, we characterized the mode of action of the ADC patritumab deruxtecan, which is a monoclonal antibody specific for Erb-B2 Receptor Tyrosine Kinase 3 ...
Sabrina Forveille, Liwei Zhao, Allan Sauvat, Giulia Cerrato, Marion Leduc, Flora Doffe, Yuhong Pan, Peng Liu, Guido Kroemer, Oliver Kepp   +9 more
doaj   +1 more source

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics

Metabolites, 2018
The annotation of small molecules remains a major challenge in untargeted mass spectrometry-based metabolomics. We here critically discuss structured elucidation approaches and software that are designed to help during the annotation of unknown compounds.
I. Blaženović, T. Kind, Jian Ji, O. Fiehn   +3 more
semanticscholar   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

XCMS-METLIN: data-driven metabolite, lipid, and chemical analysis

Molecular Systems Biology
In this Correspondence, G. Siuzdak and colleagues present XCMS-METLIN, an extensive resource for metabolomics, lipidomics, and chemical analysis.
Martin Giera, Aries Aisporna, Winnie Uritboonthai, Linh Hoang, Rico J E Derks, Kara M Joseph, Erin S Baker, Gary Siuzdak   +7 more
doaj   +1 more source

Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

Nature Protocols, 2022
Zhiqiang Pang, Guangyan Zhou, J. Ewald, Le Chang, O. Haçarız, N. Basu, J. Xia   +6 more
semanticscholar   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

MassCube improves accuracy for metabolomics data processing from raw files to phenotype classifiers

Nature Communications
Nontargeted peak detection in LC-MS-based metabolomics must become robust and benchmarked. We present MassCube, a Python-based open-source framework for MS data processing that we systematically benchmark against other algorithms and different types of ...
Huaxu Yu, Jun Ding, Tong Shen, Min Liu, Yuanyue Li, Oliver Fiehn   +5 more
doaj   +1 more source

Metabolomics for the masses: The future of metabolomics in a personalized world

European Journal of Molecular & Clinical Medicine, 2017
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules.
Trivedi, Drupad, Hollywood, Katherine, Goodacre, Royston   +2 more
openaire   +3 more sources

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis

, 2021
Cecilia Wieder, Clément Frainay, Nathalie Poupin, Pablo Rodríguez-Mier, Florence Vinson, Juliette Cooke, Rachel Lai, Jacob G. Bundy, Fabien Jourdan, Timothy M. D. Ebbels   +9 more
openalex   +1 more source