Results 261 to 270 of about 297,367 (349)

Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships

, 2019
Francesco Del Carratore, Kamila Schmidt, María Vinaixa, Katherine A. Hollywood, Caitlin Greenland-Bews, Eriko Takano, Simon Rogers, Rainer Breitling   +7 more
openalex   +1 more source

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

Advanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li, Ziyan Song, Jianjun Ding, Yiheng Zhou, Tianning Huang, Qufei Qian, Miao Yu, Wenzhao Chen, Jiazheng Liu, Ling Lu, Qiuyang Chen   +10 more
wiley   +1 more source

Advancing Non-Small-Cell Lung Cancer Management Through Multi-Omics Integration: Insights from Genomics, Metabolomics, and Radiomics. [PDF]

Diagnostics (Basel)
Pierri M, Ciani G, Brunese MC, Lauro G, Terracciano S, Iorizzi M, Nardone V, Chini MG, Bifulco G, Cappabianca S, Reginelli A.   +10 more
europepmc   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Integrative Metabolic-Flux Platform for Analysis, Contextualization, and Targeting (IMPACT): bridging untargeted and targeted flux analysis. [PDF]

Bioinformatics
Starke C, Hendriks J, Wahrheit J, Fluitman F, Beekwilder J, Schempp FM, Hiller K.   +6 more
europepmc   +1 more source

Metabolomics and Isotope Tracing

Cell, 2018
Cholsoon Jang, Li Chen, J. Rabinowitz
semanticscholar   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Global research trends and emerging themes in osteosarcoma metabolomics: a bibliometric and visualization analysis. [PDF]

Front Mol Biosci
Wu H, Xu K, Liu C, Ge H, Yan J.
europepmc   +1 more source

Untargeted Metabolomics Strategies—Challenges and Emerging Directions

Journal of the American Society for Mass Spectrometry, 2016
Alexandra C. Schrimpe‐Rutledge, S. Codreanu, S. Sherrod, J. McLean   +3 more
semanticscholar   +1 more source