Results 121 to 130 of about 60,060 (230)

Metabotropic glutamate receptor 5: a target for migraine therapy

Annals of Clinical and Translational Neurology, 2016
Introduction Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy.
Maggie W. Waung, Simon Akerman, Mark Wakefield, Charlotte Keywood, Peter J. Goadsby   +4 more
doaj   +1 more source

Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]

, 2018
Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya, Gearhart, Jeffery M, Grobe, Nadja, Hoffmann, Andrea, Kim, Dong-Suk, Mahama, Belinda, Meade, Mitchell L, Rumbeiha, Wilson K, Whitley, Elizabeth M   +8 more
core  

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells

Nature Communications
Glutamate, a crucial player in hepatic amino acid metabolism, has been relatively unexplored in immune cell activation. We show in a study with male mice that hepatic glutamate accumulates in vesicles of perivenous hepatocytes through vesicular glutamate
Keungmo Yang, Kyurae Kim, Tom Ryu, Young-Ri Shim, Hee-Hoon Kim, Sung Eun Choi, Min Jeong Kim, Katherine Po Sin Chung, Eunmi Lee, Kwang Woo Lee, Jehwi Jeon, Pilhan Kim, Young Seo Kim, Taeyun Ku, Haengdueng Jeong, Ki Taek Nam, Gyumin Lim, Dong Wook Choi, Seok-Hwan Kim, Hyuk Soo Eun, Won Kim, Won-Il Jeong   +21 more
doaj   +1 more source

CryoEM structure of mGlu6 captures receptor activation prior to G protein coupling

Nature Communications
The metabotropic glutamate receptor 6 (mGlu6) is essential for synaptic communication of rod photoreceptors, and mutations in mGlu6 lead to a blinding disorder. However, its structural organization remains unknown.
Seo Young Lee, Chu-Ting Chang, Yaejin Yun, Jeong Seok Ji, Kirill A. Martemyanov, Hyung Ho Lee   +5 more
doaj   +1 more source

Neurotransmitter signaling in white matter [PDF]

, 2014
Butt, Arthur M., Fern, Robert F., Matute, Carlos   +2 more
core   +1 more source

Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis. [PDF]

Sci Rep
Kwak Y, Kim B, Seok J, Lee M, Cho SG, Kim S, Yoon H, Kim A.   +7 more
europepmc   +1 more source

Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus. [PDF]

Biomedicines
Raiteri L, Cerminara M, Puliti A, Pittaluga A.   +3 more
europepmc   +1 more source

Metabotropic glutamate receptor 5 in the anterior cingulate cortex predicts individual differences in motor impulsivity but not in risky decision-making. [PDF]

Transl Psychiatry
Marchessaux F, Arrondeau C, Goutaudier R, Urueña-Méndez G, Ginovart N.   +4 more
europepmc   +1 more source

Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia. [PDF]

J Small Anim Pract
Glovéus A, Ekstrand C, Flöhr A, Viskjer S, Höglund O.   +4 more
europepmc   +1 more source

Metabotropic glutamate receptor homo- and heterodimers exhibit distinct responses to orthosteric and allosteric ligands. [PDF]

Mol Pharmacol
McCullock TW, Couch T, Kammermeier PJ.
europepmc   +1 more source