Results 151 to 160 of about 54,675 (202)
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Metabotropic Glutamate Receptors and Neurodegeneration
2004Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria +7 more
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A family of metabotropic glutamate receptors
Neuron, 1992Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Yasuto Tanabe +4 more
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Metabotropic glutamate receptors and epilepsy
Journal of the Neurological Sciences, 2006Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Michel Baudry +2 more
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Metabotropic Glutamate Receptors in Glial Cells
Neurochemical Research, 2008Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and metabotropic glutamate (mGlu) receptors. In addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes ...
Simona D'Antoni +6 more
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Metabotropic Glutamate Receptors as Drug Targets
Current Drug Targets, 2007L-glutamate (Glu), the main excitatory amino acid neurotransmitter in the mammalian central nervous system, is involved in many physiological functions, including learning and memory, but also in toxic phenomena occurring in numerous degenerative or neurological diseases.
Récasens, Max +4 more
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Dynamics and modulation of metabotropic glutamate receptors
Current Opinion in Pharmacology, 2015The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
Jean-Philippe Pin +3 more
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Metabotropic glutamate receptors, 5 years on
Neuropharmacology, 2017[no abstract]
Collingridge, Graham L. +3 more
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Metabotropic receptors for glutamate and GABA in pain
Brain Research Reviews, 2009Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: ionotropic and metabotropic receptors.
Cyril Goudet +8 more
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Immunohistochemical visualization of a metabotropic glutamate receptor
NeuroReport, 1993The immunocytochemical localization of the recently cloned metabotropic glutamate receptor 1 alpha (mGluR1 alpha) was demonstrated with a C-terminus specific antibody in rat cerebellar cortex. This antibody detects a 138-140 kDa major, and a 46 kDa minor band in membrane preparations of rat cortex and cerebellum.
Görcs Tamás Jenő +4 more
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2008 Eruptions in metabotropic glutamate receptors
Neuropharmacology, 2008[No abstract available]
NICOLETTI, Ferdinando +2 more
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