Results 181 to 190 of about 60,060 (230)
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Metabotropic glutamate receptors
Cell and Tissue Research, 2006Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
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Metabotropic glutamate receptors
Pharmacology Biochemistry and Behavior, 2002Abstract Glutamate, like other neurotransmitters (acetylcholine, ATP, serotonine, glycine, GABA), acts on two main types of membrane receptors: ligand-gated channels, also called ionotropic receptors (iGluRs), and G protein coupled receptors also called metabotropic glutamate receptors (mGluRs).
Darryle D Schoepp, P.Jeffrey Conn
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Metabotropic Glutamate Receptors
Amino Acids, 2007l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs).
A. Pilc, K. Ossowska
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Metabotropic glutamate receptors and epilepsy
Journal of the Neurological Sciences, 2006Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Jorge, Ure +2 more
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Estrogen receptor signaling through metabotropic glutamate receptors
2020As the non-nuclear initiated effects of steroid hormone signaling have become more widely accepted, there has been a need to define the novel mechanisms of hormone receptor action that account for these outcomes. One mechanism that has emerged is the coupling of classical estrogen receptors (ERα and ERβ) with metabotropic glutamate receptors (mGluRs ...
Kellie S, Gross, Paul G, Mermelstein
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Metabotropic Glutamate Receptors and Neuronal Toxicity
1992Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G +7 more
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Metabotropic Glutamate Receptors and Neurodegeneration
2004Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria +2 more
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Metabotropic glutamate receptors and neurodegeneration.
Progress in brain research, 1998Metabotropic glutamate (mGlu) receptors belong to a class of G-protein linked receptors, which also includes the Ca2+-sensing receptor and the gama-aminobutyric acid (GABAB) receptor. A great variety of drugs has been introduced with the intent of limiting some of the intracellular events that occur downstream of the increase in intracellular Ca2 ...
BRUNO, Valeria Maria Gloria +7 more
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