Results 11 to 20 of about 89,220 (264)

Metabotropic glutamate receptor trafficking [PDF]

Molecular and Cellular Neuroscience, 2018
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh, K. Chang, K. Roche
semanticscholar   +4 more sources

Metabotropic glutamate receptors in cancer [PDF]

Neuropharmacology, 2017
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen, Brian A. Wall, Janet Wangari-Talbot, Lumeng J. Yu   +3 more
openaire   +3 more sources

Optical control of metabotropic glutamate receptors [PDF]

Nature Neuroscience, 2013
G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Harald Janovjak, Harald Janovjak, Ehud Y. Isacoff, Dirk Trauner, Dirk Trauner, David Schoppik, Andreas Reiner, Benjamin M. Gaub, Joshua Levitz, Adam Hoagland, Philipp Stawski, Alexander F. Schier, Brian Kane, Carlos R. Pantoja   +13 more
openaire   +4 more sources

Kinetic fingerprinting of metabotropic glutamate receptors

Communications Biology, 2023
AbstractDimeric metabotropic glutamate receptors (mGluRs) are abundantly expressed in neurons. In mammals, eight subunit isoforms, mGluR1-8, have been identified, forming the groups I, II, and III. We investigated receptor dimerization and kinetics of these mGluR isoforms in excised membrane patches by FRET and confocal patch-clamp fluorometry. We show
Taulant Kukaj, Christian Sattler, Thomas Zimmer, Ralf Schmauder, Klaus Benndorf   +4 more
openaire   +3 more sources

Metabotropic Glutamate Receptors and Epileptogenesis

Epilepsy Currents, 2002
Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus.
Robert K. S. Wong, Riccardo Bianchi, Shih-Chieh Chuang   +2 more
openaire   +3 more sources

Metabotropic Receptors for Glutamate and GABA [PDF]

, 2012
G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and due to their ubiquitous expression and vast array of functions they present attractive targets for the treatment of a wide number of diseases and disorders.
Laurent Prézeau, Cyril Goudet, Philippe Rondard, Julie Kniazeff, Jean-Philippe Pin, Gregory D. Stewart   +5 more
openaire   +3 more sources

Analyses of GWAS and Sub‐Threshold Loci Lead to the Discovery of Dendrite Development and Morphology Dysfunction Underlying Schizophrenia Genetic Risk

Advanced Science, EarlyView.
A cost‐effective strategy is developed analyzing sub‐threshold GWAS loci (5 × 10−8 < P ≤ 10−6), identifying 180 risk loci and 304 high‐confidence genes through combined GWAS/subGWAS analysis. This approach reveals dendrite development and morphogenesis (DDM) as a novel SCZ pathway.
Rui Chen, Benjamin Siciliano, Quan Wang, Chongchong Xu, Qiang Wei, Hai Yang, James S Sutcliffe, Yi Jiang, Ying Ji, Chunyu Liu, Feixiong Cheng, Edwin H Cook, Nancy J Cox, Xue Zhong, Zhexing Wen, Bingshan Li   +15 more
wiley   +1 more source

Assembly and Cooperativity of Metabotropic Glutamate Receptors [PDF]

Biophysical Journal, 2015
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are found throughout the nervous system where they respond to the major excitatory neurotransmitter, glutamate, to modulate synaptic transmission and plasticity via a variety of effectors.
Levitz, Josh, Vafabakhsh, Reza, Bharill, Shashank, Bharill, Shashank, Isacoff, Ehud Y.   +4 more
openaire   +2 more sources

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Metabotropic glutamate receptors: Phosphorylation and receptor signaling

Journal of Neuroscience Research, 2007
AbstractMetabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of ...
Jinu Lee, Katherine W. Roche, Jae-Youn Lee, Chul Hoon Kim   +3 more
openaire   +3 more sources