Metabotropic glutamate receptor agonists for schizophrenia [PDF]
British Journal of Psychiatry, 2008 SummaryA drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.
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Activation requirements for metabotropic glutamate receptors [PDF]
Neuroscience Letters, 2013 It has been common experimentally to use high frequency, tetanic, stimulation to activate metabotropic glutamate receptors (mGluRs) in cortex and thalamus. To determine what type of stimulation is actually necessary to activate mGluRs we examined the effects of varying stimulation duration and intensity on activating mGluR responses.
S. Murray Sherman +2 more
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Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were
Steven W. Barger +3 more
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Metabotropic glutamate receptors in auditory processing [PDF]
Neuroscience, 2014 As the major excitatory neurotransmitter used in the vertebrate brain, glutamate activates ionotropic and metabotropic glutamate receptors (mGluRs), which mediate fast and slow neuronal actions, respectively. Important modulatory roles of mGluRs have been shown in many brain areas, and drugs targeting mGluRs have been developed for the treatment of ...
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Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers. [PDF]
Sci Adv, 2023 Lee J +8 more
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Metabotropic Glutamate Receptors and Epileptiform Bursting
Epilepsy Currents, 2002 Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts Merlin LR J Neurophysiol 2002;87:621–625 Purpose Transient activation of group I metabotropic glutamate receptors (mGluRs) with the selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) produces persistent prolongation of epileptiform bursts in guinea ...
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Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis. [PDF]
Neural Regen Res, 2023 Yeung JH, Kwakowsky A.
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Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. [PDF]
Transl Psychiatry, 2023 Kroll SL +12 more
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Concerted conformational changes control metabotropic glutamate receptor activity. [PDF]
Sci Adv, 2023 Lecat-Guillet N +12 more
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Sleep problems in old age: metabotropic glutamate receptor to the rescue. [PDF]
Sleep, 2023 Inami S, Afonso DJS, Koh K.
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