Results 11 to 20 of about 60,060 (230)

Stepwise activation of a metabotropic glutamate receptor. [PDF]

Nature
Krishna Kumar K, Wang H, Habrian C, Latorraca NR, Xu J, O'Brien ES, Zhang C, Montabana E, Koehl A, Marqusee S, Isacoff EY, Kobilka BK.   +11 more
europepmc   +2 more sources

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma

Cell Death and Disease, 2021
Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph   +17 more
doaj   +1 more source

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +6 more sources

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj   +1 more source

Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction. [PDF]

, 2016
BACKGROUND: A difficult problem in treating opioid addicts is the maintenance of a drug-free state because of the negative emotional symptoms associated with withdrawal, which may trigger relapse.
Bailey, A, Chen, Y, Georgiou, P, Gonzalez, LR, Hourani, S, Kieffer, BL, Kitchen, I, Winsky-Sommerer, R, Zanos, P   +8 more
core   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors

Frontiers in Cellular Neuroscience, 2019
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun, Yongjun Sun, Xue Feng, Yue Ding, Mengting Li, Jun Yao, Long Wang, Zibin Gao, Zibin Gao   +8 more
doaj   +1 more source

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source