Results 261 to 270 of about 122,067 (322)

Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells

Hepatology, 2021
The important roles of glutamate and metabotropic glutamate receptor 5 (mGluR5) in HSCs have recently been reported in various liver diseases; however, the mechanism linking the glutamine/glutamate metabolism and mGluR5 in liver fibrosis remains unclear.
Won-Mook Choi, Tom Ryu, Jun‐Hee Lee, Young-Ri Shim, Myung-Ho Kim, Hee-Hoon Kim, Y. Kim, Keungmo Yang, Kyurae Kim, Sung-E Choi, Won Kim, Seok-Hwan Kim, H. Eun, W. Jeong   +13 more
semanticscholar   +1 more source

Metabotropic glutamate receptors

Pharmacology Biochemistry and Behavior, 2002
Abstract Glutamate, like other neurotransmitters (acetylcholine, ATP, serotonine, glycine, GABA), acts on two main types of membrane receptors: ligand-gated channels, also called ionotropic receptors (iGluRs), and G protein coupled receptors also called metabotropic glutamate receptors (mGluRs).
Darryle D Schoepp, P.Jeffrey Conn
  +5 more sources

A family of metabotropic glutamate receptors

Neuron, 1992
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Y, Tanabe, M, Masu, T, Ishii, R, Shigemoto, S, Nakanishi   +4 more
openaire   +2 more sources

Structure of the metabotropic glutamate receptor

Current Opinion in Neurobiology, 2003
In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors.
Hisato, Jingami, Shigetada, Nakanishi, Kosuke, Morikawa   +2 more
openaire   +2 more sources

Metabotropic glutamate receptors and epilepsy

Journal of the Neurological Sciences, 2006
Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Jorge, Ure, Michel, Baudry, Mónica, Perassolo   +2 more
openaire   +2 more sources

Metabotropic Glutamate Receptors and Neurodegeneration

2004
Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, NICOLETTI, Ferdinando   +2 more
openaire   +2 more sources

Metabotropic Glutamate Receptors

Amino Acids, 2007
l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs).
A. Pilc, K. Ossowska
openaire   +2 more sources

Metabotropic glutamate receptors and neurodegeneration.

Progress in brain research, 1998
Metabotropic glutamate (mGlu) receptors belong to a class of G-protein linked receptors, which also includes the Ca2+-sensing receptor and the gama-aminobutyric acid (GABAB) receptor. A great variety of drugs has been introduced with the intent of limiting some of the intracellular events that occur downstream of the increase in intracellular Ca2 ...
BRUNO, Valeria Maria Gloria, BATTAGLIA, Giuseppe, A. Copani, G. Casabona, M. Storto, V. D. Giorgi, R. Ngomba, NICOLETTI, Ferdinando   +7 more
openaire   +3 more sources

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

Nature, 2021
Shuling Lin, Shuo Han, Xiao-qing Cai, Q. Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, C. Yi, Xiaojing Chu, A. Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang, Qiang Zhao, Beili Wu   +19 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptors and Neuronal Toxicity

1992
Specific glutamate receptors coupled to polyphosphoinositide (PPI) hydrolysis have been described in brain slices, cultured neurons, and astrocytes, and in amphibian oocytes injected with rat brain mRNA (Sladeczek et al., 1985; Nicoletti et al., 1986a,b; Sugiyama et al., 1987).
ALEPPO G, PISANI A, COPANI A, BRUNO V, ARONICA E, D'AGATA V, CANONICO P. L, NICOLETTI F   +7 more
openaire   +6 more sources