Results 41 to 50 of about 63,134 (262)

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

open access: yes, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys   +78 more
core   +2 more sources

Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception

open access: yesMolecular Pain, 2012
Background Interstitial cystitis/painful bladder syndrome (IC/PBS), is a severely debilitating chronic condition that is frequently unresponsive to conventional pain medications.
Crock Lara W   +8 more
doaj   +1 more source

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

open access: yeseLife, 2020
Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, yet they don’t bind glutamate and are considered orphan. Progress in defining the ion channel function of GluDs in neurons has been hindered by a lack of pharmacological
Damien Lemoine   +7 more
doaj   +1 more source

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. [PDF]

open access: yes, 2015
Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial ...
BATTAGLIA, Giuseppe   +8 more
core   +1 more source

Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2

open access: yeseLife, 2020
Metabotropic glutamate receptors (mGluRs) play an important role in synaptic plasticity and memory and are largely classified based on amino acid sequence homology and pharmacological properties.
Ananya Dasgupta   +7 more
doaj   +1 more source

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]

open access: yes, 2014
BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna   +9 more
core   +3 more sources

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction:Combining preclinical evidence with human Positron Emission Tomography (PET) studies

open access: yesFrontiers in Neuroscience, 2015
In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck   +3 more
doaj   +1 more source

Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]

open access: yesPLoS ONE, 2010
Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen   +3 more
doaj   +1 more source

Assembly and Cooperativity of Metabotropic Glutamate Receptors [PDF]

open access: yesBiophysical Journal, 2015
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are found throughout the nervous system where they respond to the major excitatory neurotransmitter, glutamate, to modulate synaptic transmission and plasticity via a variety of effectors.
Levitz, Josh   +4 more
openaire   +2 more sources

Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]

open access: yes, 2010
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa   +11 more
core   +2 more sources

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