Results 51 to 60 of about 89,220 (264)
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?
Frontiers in Molecular Neuroscience, 2018 Neurodegenerative disorders are characterized by excitotoxicity and neuroinflammation that finally lead to slow neuronal degeneration and death. Although neurons are the principal target, glial cells are important players as they contribute by either ...
S. Spampinato +4 more
semanticscholar +1 more source
Addiction Biology, Volume 30, Issue 9, September 2025.ABSTRACT Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro‐drug, N‐acetyl‐cysteine (NAC), is a promising glutamatergic agent that has shown some clinical efficacy in reducing nicotine use in humans.
Kelsey Stoddart +5 more
wiley +1 more source
Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine [PDF]
, 1993 D G Winder, P. Jeffrey Conn
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Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.Controlling protein interactions is key to studying signaling. Antibody methods have limits, but chemical inducers of dimerization (CIDs) using HaloTags and SNAP‐Tags offer precise control. We present CIDs to covalently link heteromers with varied linkers and a FRET‐based sensor.
Michael Trumpp +8 more
wiley +1 more source
Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4 [PDF]
, 1993 Yasuto Tanabe +5 more
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Human Brain Mapping, Volume 46, Issue 12, 15 August 2025.By harmonizing resting‐state fMRI data from a relatively large multi‐site sample, this study reveals altered modular dynamics in schizophrenia. These alterations are associated with multiple neurotransmitter systems and transcriptomic profiles that are preferentially enriched for biological processes of transmembrane transport and brain development, as
Yi Zhen +5 more
wiley +1 more source
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, Volume 12, Issue 29, August 7, 2025.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. [PDF]
, 1994 Jean‐Philippe Pin +3 more
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The Role of Peripheral N‐Methyl‐D‐Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review
European Journal of Pain, Volume 29, Issue 7, August 2025.ABSTRACT Background and Objective NMDA receptors, predominantly located in the central nervous system and known for their roles in synaptic plasticity and central sensitisation of pain and itch, are also expressed in peripheral sensory neurons. Emerging evidence suggests that peripheral NMDA receptors contribute to pathological pain and potentially ...
Ryusuke Tanaka +3 more
wiley +1 more source