Results 61 to 70 of about 62,813 (331)
Neuroadaptations in the Cellular and Postsynaptic Group 1 Metabotropic Glutamate Receptor mGluR5 and Homer Proteins Following Extinction of Cocaine Self-administration [PDF]
, 2009 This study examined the role of group1 metabotropic glutamate receptor mGluR5 and associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration.
Ghasemzadeh, M. Behnam +4 more
core +2 more sources
Assembly and Cooperativity of Metabotropic Glutamate Receptors [PDF]
Biophysical Journal, 2015 Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are found throughout the nervous system where they respond to the major excitatory neurotransmitter, glutamate, to modulate synaptic transmission and plasticity via a variety of effectors.
Levitz, Josh +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels [PDF]
arXiv, 2022 Perhaps the most important question posed by brain research is: How the brain gives rise to the mind. To answer this question, we have primarily relied on the connectionist paradigm: The brain's entire knowledge and thinking skills are thought to be stored in the connections; and the mental operations are executed by network computations.
arxiv
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]
, 2014 BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna +9 more
core +3 more sources
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
Frontiers in Neuroscience, 2015 In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck +3 more
doaj +1 more source
eLife, 2020 Metabotropic glutamate receptors (mGluRs) play an important role in synaptic plasticity and memory and are largely classified based on amino acid sequence homology and pharmacological properties.
Ananya Dasgupta +7 more
doaj +1 more source
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +1 more source
Advanced Science, EarlyView.GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou +18 more
wiley +1 more source