Results 81 to 90 of about 122,067 (322)

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

Molecules, 2023
Isoxazolo[3,4-d] pyridazinones ([3,4-d]s) were previously shown to have selective positive modulation at the metabotropic glutamate receptor (mGluR) Subtypes 2 and 4, with no functional cross-reactivity at mGluR1a, mGluR5, or mGluR8.
Christina A. Gates, Donald S. Backos, Philip Reigan, Nicholas R. Natale   +3 more
doaj   +1 more source

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. [PDF]

, 2012
Protein synthesis is highly regulated throughout nervous system development, plasticity and regeneration. However, tracking the distributions of specific new protein species has not been possible in living neurons or at the ultrastructural level ...
Butko, Margaret T, Ellisman, Mark H, Geng, Yang, Jeon, Noo Li, Kim, Hyung Joon, Lin, Michael Z, Mackey, Mason R, Shu, Xiaokun, Tsien, Roger Y, Yang, Jin   +9 more
core   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
core   +2 more sources

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, EarlyView.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel   +6 more
wiley   +1 more source

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

BMC Neuroscience, 2008
Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana, Blomqvist Anna, Kindlundh-Högberg Anna MS, Schiöth Helgi B   +3 more
doaj   +1 more source

Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]

, 2011
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun, Crawford, Devon C, Hyrc, Krzysztof L, Mennerick, Steven   +3 more
core   +2 more sources