Results 81 to 90 of about 89,220 (264)

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.

Brain : a journal of neurology, 2016
L. Haas, Santiago V. Salazar, M. Kostylev, J. Um, A. Kaufman, S. Strittmatter   +5 more
semanticscholar   +1 more source

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Metabotropic Glutamate Receptors and Epileptiform Bursting

Epilepsy Currents, 2002
Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts Merlin LR J Neurophysiol 2002;87:621–625 Purpose Transient activation of group I metabotropic glutamate receptors (mGluRs) with the selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) produces persistent prolongation of epileptiform bursts in guinea ...
openaire   +3 more sources

Axon/Dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy-Terminal Domains [PDF]

, 1999
Julia Nash Stowell, Ann Marie Craig
openalex   +1 more source

Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT Anxiety disorders rank among the most prevalent mental health conditions worldwide, significantly affecting patients' lives. They are frequently comorbid with other psychiatric disorders, often exacerbating their severity. Current pharmacological treatments; selective serotonin reuptake inhibitors (SSRIs) and benzodiazepines, remain limited in
Salma R. Abdennebi, Nour El Haya Touihri, Emmanuelle Corruble, Denis J. David, Indira Mendez‐David   +4 more
wiley   +1 more source

Metabotropic glutamate receptors trigger postsynaptic protein synthesis.

, 1993
Ivan Jeanne Weiler, William T. Greenough
openalex   +1 more source

Functional Switch from Facilitation to Inhibition in the Control of Glutamate Release by Metabotropic Glutamate Receptors [PDF]

, 1998
I. Herrero, María Teresa Miras‐Portugal, José Sánchez‐Prieto   +2 more
openalex   +1 more source

Metabotropic glutamate receptor type 1 autoimmunity

Neurology, 2016
A. S. Lopez-Chiriboga, L. Komorowski, T. Kümpfel, C. Probst, Shannon R. Hinson, S. Pittock, A. McKeon   +6 more
semanticscholar   +1 more source

MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
The observations suggest a new mechanism, the mGluR5/PKCδ/PDH axis by which extracellular glutamate can raise oxidative metabolism in astrocytes, in response to rapidly increasing energy demands, such as in the liver or skeletal muscle. It appears that the plethora of astrocytic mitochondria maintain only a basal level of oxidative metabolism during ...
Kiavasch M. N. Farid, Rodrigo Lerchundi, Christine R. Rose, Amin Derouiche   +3 more
wiley   +1 more source

EpileptogenesisIn VivoEnhances the Sensitivity of Inhibitory Presynaptic Metabotropic Glutamate Receptors in Basolateral Amygdala NeuronsIn Vitro [PDF]

, 1997
Volker Neugebauer, N. Bradley Keele, Patricia Shinnick‐Gallagher   +2 more
openalex   +1 more source