Results 1 to 10 of about 577,902 (280)

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2 [PDF]

eLife, 2022
Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein binding site. Factors that bind at non-cognate ligand binding sites to alter the
Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh   +5 more
doaj   +5 more sources

Homology modelling of metabotropic glutamate receptor 2 [PDF]

Journal of Cheminformatics, 2011
Many studies show involvement of metabotropic glutamate receptors (mGluRs) in synaptic excitation transudation. The mGluR family consists of eight proteins divided into three groups corresponding to sequence similarities, pharmacology and physiological role. These groups are: I (mGluR1, -5), II (mGluR2, -3) and III (mGluR4, -6, -7, -8).
Mordalski S, Kosciolek T, Ravna A, Sylte I, Bojarski AJ   +4 more
doaj   +6 more sources

Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2020
Objective To report the presence of a new neuronal surface antibody against the metabotropic glutamate receptor 2 antibody (mGluR2-Ab) in 2 patients with paraneoplastic cerebellar ataxia.
Ruiz-García R, Martínez-Hernández E, Joubert B, Petit-Pedrol M, Pajarón-Boix E, Fernández V, Salais L, Del Pozo M, Armangué T, Sabater L, Dalmau J, Graus F.   +11 more
europepmc   +7 more sources

Exploring the activation mechanism of metabotropic glutamate receptor 2. [PDF]

Proc Natl Acad Sci U S A
Significance The G protein-coupled receptors (GPCRs) form a prominent group of cell receptors, deeply involved in the regulation of key physiological mechanisms in all major organ systems.
Zhu X, Luo M, An K, Shi D, Hou T, Warshel A, Bai C.   +6 more
europepmc   +3 more sources

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus. [PDF]

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu   +12 more
doaj   +6 more sources

Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. [PDF]

Proc Natl Acad Sci U S A, 2013
Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part because of the rarity of many causative variants and the heterogeneity and small effect size of the causal loci. Artificially
Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD, Yuan Q, Barbier E, Feng A, Flanigan M, Augier E, Enoch MA, Hodgkinson CA, Shen PH, Lovinger DM, Edenberg HJ, Heilig M, Goldman D.   +17 more
europepmc   +6 more sources

Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum. [PDF]

Neuropharmacology, 2017
The striatum plays critical roles in action control and cognition, and activity of striatal neurons is driven by glutamatergic input. Inhibition of glutamatergic inputs to projection neurons and interneurons of the striatum by presynaptic G protein-coupled receptors (GPCRs) stands to modulate striatal output and striatum-dependent behaviors.
Johnson KA, Mateo Y, Lovinger DM.
europepmc   +5 more sources

Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism [PDF]

Cells, 2023
Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD).
Kevin Domanegg, Wolfgang H. Sommer, Marcus W. Meinhardt   +2 more
doaj   +4 more sources

Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2. [PDF]

Br J Pharmacol, 2015
The activation of the metabotropic glutamate receptor 2 (mGlu2) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can
Farinha A, Lavreysen H, Peeters L, Russo B, Masure S, Trabanco AA, Cid J, Tresadern G.   +7 more
europepmc   +5 more sources

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010
Clinical, postmortem and preclinical research strongly implicates dysregulation of glutamatergic neurotransmission in major depressive disorder (MDD). Recently, metabotropic glutamate receptors (mGluRs) have been proposed as attractive targets for the discovery of novel therapeutic approaches against depression.
A. Feyissa, W. Woolverton, J. Miguel-Hidalgo, Zhixia Wang, P. Kyle, G. Hasler, C. Stockmeier, A. Iyo, B. Karolewicz   +8 more
semanticscholar   +4 more sources