Results 1 to 10 of about 52,982 (243)

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2 [PDF]

eLife, 2022
Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein binding site. Factors that bind at non-cognate ligand binding sites to alter the
Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh   +5 more
doaj   +5 more sources

Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2020
Objective To report the presence of a new neuronal surface antibody against the metabotropic glutamate receptor 2 antibody (mGluR2-Ab) in 2 patients with paraneoplastic cerebellar ataxia.
Ruiz-García R, Martínez-Hernández E, Joubert B, Petit-Pedrol M, Pajarón-Boix E, Fernández V, Salais L, Del Pozo M, Armangué T, Sabater L, Dalmau J, Graus F.   +11 more
europepmc   +7 more sources

Exploring the activation mechanism of metabotropic glutamate receptor 2. [PDF]

Proc Natl Acad Sci U S A
Significance The G protein-coupled receptors (GPCRs) form a prominent group of cell receptors, deeply involved in the regulation of key physiological mechanisms in all major organ systems.
Zhu X, Luo M, An K, Shi D, Hou T, Warshel A, Bai C.   +6 more
europepmc   +4 more sources

Homology modelling of metabotropic glutamate receptor 2 [PDF]

Journal of Cheminformatics, 2011
Many studies show involvement of metabotropic glutamate receptors (mGluRs) in synaptic excitation transudation. The mGluR family consists of eight proteins divided into three groups corresponding to sequence similarities, pharmacology and physiological ...
Mordalski S, Kosciolek T, Ravna A, Sylte I, Bojarski AJ   +4 more
doaj   +4 more sources

Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism [PDF]

Cells, 2023
Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD).
Kevin Domanegg, Wolfgang H. Sommer, Marcus W. Meinhardt   +2 more
doaj   +4 more sources

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus.

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu   +12 more
doaj   +5 more sources

A Case Series of Anti-Metabotropic Glutamate Receptor 2 Antibody-Related Diseases with Distinct Neurological Involvement [PDF]

ImmunoTargets and Therapy
Zhanwei Zhang,1 Xiaolu Deng,1 Dandan Guo,1 Jie Zhao,2 Jian Li,2 Fang He,1,3 Lifen Yang,1,3 Jing Peng1,3 1Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China; 2Department of ...
Zhang Z, Deng X, Guo D, Zhao J, Li J, He F, Yang L, Peng J   +7 more
doaj   +3 more sources

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj   +3 more sources

Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2 [PDF]

Frontiers in Molecular Neuroscience, 2017
Synaptic cell adhesion molecules represent important targets for neuronal activity-dependent proteolysis. Postsynaptic neuroligins (NLs) form trans-synaptic complexes with presynaptic neurexins (NXs). Both NXs and NLs are cleaved from the cell surface by
Michelle D. Gjørlund, Michelle D. Gjørlund, Eva M. M. Carlsen, Andreas B. Kønig, Oksana Dmytrieva, Anders V. Petersen, Jacob Jacobsen, Vladimir Berezin, Jean-François Perrier, Sylwia Owczarek   +9 more
doaj   +2 more sources

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu   +16 more
doaj   +2 more sources