Results 1 to 10 of about 25,145 (234)

Homology modelling of metabotropic glutamate receptor 2 [PDF]

Journal of Cheminformatics, 2011
Many studies show involvement of metabotropic glutamate receptors (mGluRs) in synaptic excitation transudation. The mGluR family consists of eight proteins divided into three groups corresponding to sequence similarities, pharmacology and physiological role. These groups are: I (mGluR1, -5), II (mGluR2, -3) and III (mGluR4, -6, -7, -8).
Mordalski S, Kosciolek T, Ravna A, Sylte I, Bojarski AJ   +4 more
doaj   +3 more sources

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

eLife, 2022
Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein binding site. Factors that bind at non-cognate ligand binding sites to alter the
Brandon Wey-Hung Liauw, Arash Foroutan, Michael R Schamber, Weifeng Lu, Hamid Samareh Afsari, Reza Vafabakhsh   +5 more
doaj   +3 more sources

Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus.

PLoS Pathogens, 2018
Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang, Zilong Wang, Renqiang Liu, Lei Shuai, Xinxin Wang, Jie Luo, Chong Wang, Weiye Chen, Xijun Wang, Jinying Ge, Xijun He, Zhiyuan Wen, Zhigao Bu   +12 more
doaj   +4 more sources

The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways [PDF]

Journal of Biological Chemistry, 2001
There is accumulating evidence that the specificity of the transduction cascades activated by G protein-coupled receptors cannot solely depend on the nature of the coupled G protein. To identify additional structural determinants, we studied two metabotropic glutamate (mGlu) receptors, the mGlu2 and mGlu7 receptors, that are both coupled to G(o ...
Julie Perroy, Gustavo J. Gutierrez, Vincent Coulon, Joël Bockaert, Jean‐Philippe Pin, Laurent Fagni   +5 more
openalex   +7 more sources

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Journal of Pharmacological Sciences, 2012
Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity ...
Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda   +10 more
doaj   +3 more sources

Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers [PDF]

Molecular Pharmacology, 2012
Metabotropic glutamate receptors (mGluRs) were thought until recently to function mainly as stable homodimers, but recent work suggests that heteromerization is possible. Despite the growth in available compounds targeting mGluRs, little is known about the pharmacological profile of mGluR heterodimers. Here, this question was addressed for the mGluR2/4
Paul J. Kammermeier
openalex   +3 more sources

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine‐induced down‐regulation of β‐adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands

Journal of Neurochemistry, 2005
AbstractAntidepressant drugs have a clinical latency that correlates with the development of neuroadaptive changes, including down‐regulation of β‐adrenergic receptors in different brain regions. The identification of drugs that shorten this latency will have a great impact on the treatment of major depressive disorders.
Francesco Matrisciano, Sergio Scaccianoce, Paolo Bianco, Isabella Panaccione, Anna M. Canudas, Giuseppe Battaglia, Barbara Riozzi, Richard Teke Ngomba, Gemma Molinaro, Roberto Tatarelli, Daniela Melchiorri, Ferdinando Nicoletti   +11 more
openalex   +5 more sources

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009
Clinical, postmortem and preclinical research strongly implicates dysregulation of glutamatergic neurotransmission in major depressive disorder (MDD). Recently, metabotropic glutamate receptors (mGluRs) have been proposed as attractive targets for the discovery of novel therapeutic approaches against depression.
Anteneh M. Feyissa, William L. Woolverton, José Javier Miguel-Hidalgo, Zhixia Wang, Patrick B. Kyle, Gregor Hasler, Craig A. Stockmeier, Abiye H. Iyo, Beata Karolewicz   +8 more
openalex   +3 more sources

Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism

Cells, 2023
Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved pharmacotherapies have demonstrated limited effectiveness over the last few decades in treating alcohol use disorders (AUD).
Kevin Domanegg, Wolfgang H. Sommer, Marcus W. Meinhardt   +2 more
doaj   +3 more sources

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization [PDF]

Journal of Medicinal Chemistry, 2018
Covalent labeling of G protein-coupled receptors (GPCRs) by small molecules is a powerful approach to understand binding modes, mechanism of action, pharmacology, and even facilitate structure elucidation. We report the first covalent positive allosteric modulator (PAM) for a class C GPCR, the mGlu2 receptor.
Maarten L. J. Doornbos, Xuesong Wang, Sophie C. Vermond, Luc Peeters, Laura Pérez‐Benito, Andrés A. Trabanco, Hilde Lavreysen, José M. Cid, Laura H. Heitman, Gary Tresadern, Adriaan P. IJzerman   +10 more
openalex   +6 more sources