Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
eLife, 2022 Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein binding site. Factors that bind at non-cognate ligand binding sites to alter the
Brandon Wey-Hung Liauw +5 more
doaj +4 more sources
Homology modelling of metabotropic glutamate receptor 2 [PDF]
Journal of Cheminformatics, 2011 Many studies show involvement of metabotropic glutamate receptors (mGluRs) in synaptic excitation transudation. The mGluR family consists of eight proteins divided into three groups corresponding to sequence similarities, pharmacology and physiological ...
Mordalski S +4 more
doaj +4 more sources
Metabotropic glutamate receptor subtype 2 is a cellular receptor for rabies virus.
PLoS Pathogens, 2018 Rabies virus (RABV) invades the central nervous system and nearly always causes fatal disease in humans. How RABV interacts with host neuron membrane receptors to become internalized and cause rabid symptoms is not yet fully understood.
Jinliang Wang +12 more
doaj +5 more sources
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression [PDF]
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009 Clinical, postmortem and preclinical research strongly implicates dysregulation of glutamatergic neurotransmission in major depressive disorder (MDD). Recently, metabotropic glutamate receptors (mGluRs) have been proposed as attractive targets for the discovery of novel therapeutic approaches against depression.
Anteneh M. Feyissa +8 more
semanticscholar +4 more sources
Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2 [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2019 Objective To report the presence of a new neuronal surface antibody against the metabotropic glutamate receptor 2 antibody (mGluR2-Ab) in 2 patients with paraneoplastic cerebellar ataxia.
R. Ruiz-García +11 more
semanticscholar +5 more sources
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Gene identification for complex behavioral traits, alcoholism in particular, has been largely unsuccessful, in part because of the rarity of many causative variants and the heterogeneity and small effect size of the causal loci. Artificially selected animals may be valuable in gene identification.
Zhifeng Zhou +17 more
semanticscholar +4 more sources
Pharmacology of Metabotropic Glutamate Receptor 2 Homo‐ and Heterodimers
The FASEB Journal, 2020 Metabotropic Glutamate Receptors (mGluRs) are a family of class C g‐protein coupled receptors (GPCRs) that respond to glutamate as their native agonist.
Tyler W. McCullock, P. Kammermeier
semanticscholar +2 more sources
Exploring the activation mechanism of metabotropic glutamate receptor 2
Proceedings of the National Academy of SciencesSignificance The G protein-coupled receptors (GPCRs) form a prominent group of cell receptors, deeply involved in the regulation of key physiological mechanisms in all major organ systems.
Xiaohong Zhu +6 more
semanticscholar +3 more sources
The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways [PDF]
Journal of Biological Chemistry, 2001 There is accumulating evidence that the specificity of the transduction cascades activated by G protein-coupled receptors cannot solely depend on the nature of the coupled G protein. To identify additional structural determinants, we studied two metabotropic glutamate (mGlu) receptors, the mGlu2 and mGlu7 receptors, that are both coupled to G(o ...
Julie Perroy +5 more
openalex +8 more sources
Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers [PDF]
Molecular Pharmacology, 2012 Metabotropic glutamate receptors (mGluRs) were thought until recently to function mainly as stable homodimers, but recent work suggests that heteromerization is possible. Despite the growth in available compounds targeting mGluRs, little is known about the pharmacological profile of mGluR heterodimers. Here, this question was addressed for the mGluR2/4
Paul J. Kammermeier
openalex +3 more sources